Real-time monitoring of hydrogel phase transition in an ultrahigh Q microbubble resonator  

作　　者：DAQUAN YANG AIQIANG WANG JIN-HUI CHEN XIAO-CHONG YU CHUWEN LAN YUEFENG JI YUN-FENG XIAO 

机构地区：[1]State Key Laboratory of Information Photonics and Optical Communications,School of Information and Communication Engineering,Beijing University of Posts and Telecommunications,Beijing 100876,China [2]State Key Laboratory for Artificial Microstructure and Mesoscopic Physics,School of Physics,Peking University,Beijing 100871,China [3]Frontiers Science Center for Nano-optoelectronics&Collaborative Innovation Center of Quantum Matter,Beijing 100871,China [4]Collaborative Innovation Center of Extreme Optics,Shanxi University,Taiyuan 030006,China [5]Beijing Academy of Quantum Information Sciences,Beijing 100193,China

出　　处：《Photonics Research》2020年第4期497-502,共6页光子学研究（英文版）

基　　金：National Key Research and Development Program of China(2018YFB2200401,2016YFA0301302);National Natural Science Foundation of China(11654003,11825402,11974058,61435001);Key R&D Program of Guangdong Province(2018B030329001);Fundamental Research Funds for the Central Universities(2018XKJC05);State Key Laboratory of Information Photonics and Optical Communications(IPOC2019ZT03)。

摘　　要：The ability to sense dynamic biochemical reactions and material processes is particularly crucial for a wide range of applications,such as early-stage disease diagnosis and biomedicine development.Optical microcavities-based label-free biosensors are renowned for ultrahigh sensitivities,and the detection limit has reached a single nanoparticle/molecule level.In particular,a microbubble resonator combined with an ultrahigh quality factor(Q)and inherent microfluidic channel is an intriguing platform for optical biosensing in an aqueous environment.In this work,an ultrahigh Q microbubble resonator-based sensor is used to characterize dynamic phase transition of a thermosensitive hydrogel.Experimentally,by monitoring resonance wavelength shift and linewidth broadening,we(for the first time to our knowledge)reveal that the refractive index is increased and light scattering is enhanced simultaneously during the hydrogel hydrophobic transition process.The platform demonstrated here paves the way to microfluidical biochemical dynamic detection and can be further adapted to investigating single-molecule kinetics.

关 键 词：Real-time monitoring hydrogel phase transition an ultrahigh Q microbubble resonator 

分 类 号：TN751.2[电子电信—电路与系统] TQ427.26[化学工程]