多目标遗传算法优化复方红黄口含片水提工艺  

Optimization of Water Extraction Process of Compound Honghuang Buccal Tablets by Multi-objective Genetic Algorithm

作　　者：李琳[1] 张国强[1] 石晓峰[1,2] 马趣环[2] 范彬[2] 沈薇[2] LI Lin;ZHANG Guoqiang;SHI Xiaofeng;MA Quhuan;FAN Bin;SHEN Wei(Gansu University of TCM,Lanzhou 730030,China;Gansu Academy of Medical Science,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,兰州730030 [2]甘肃省医学科学研究院,兰州730050

出　　处：《中国现代应用药学》2020年第9期1063-1068,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：甘肃省省级引导科技创新发展专项资金竞争性项目(17);兰州市人才创新创业项目(2017-RC-28)。

摘　　要：目的优选复方红黄口含片水提工艺。方法以加水倍数、提取时间、提取次数为考察因素,以总多糖含量和浸膏得率为考察指标,进行正交试验。运用Minitab 18.0软件建立总多糖含量和浸膏得率的二次回归模型,进一步运用多目标遗传算法优化正交试验结果,确定复方红黄口含片的最优水提工艺。结果优选得到的最佳水提工艺为加水10倍量、煎煮3次、每次2.94 h。结论所得工艺稳定可行,有效成分得率高,可用于复方红黄口含片的提取。OBJECTIVE To optimize the water extraction process of compound Honghuang buccal tablets.METHODS The water addition ratio,extraction time and extraction frequency were selected as the investigate factors,and the orthogonal test was carried out with the total polysaccharides content and extraction yield as the inspection indexes.A quadratic regression model of total polysaccharide content and extraction yield was established by Minitab 18.0 software,further multi-objective genetic algorithm was used to optimize the orthogonal test results and determine the optimal extraction process of compound Honghuang buccal tablets.RESULTS The optimal extraction process was as follows:10 times the amount of water,reflux extraction 3 times,2.94 h for each time.CONCLUSION The optimized extraction process is stable and feasible,and the rates of extracting effective ingredients is high.It can be used to extract compound Honghuang buccal tablets.

关 键 词：复方红黄口含片 提取工艺 总多糖 浸膏得率 多目标遗传算法 

分 类 号：R284.2[医药卫生—中药学]