人细小病毒B19分子生物学研究进展  

Advances in molecular biology research on human parvovirus B19

作　　者：董衍明 李京京 徐鹏 李毅[4] 马立新[1] 王媛 Yanming Dong;Jingjing Li;Peng Xu;Yi Li;Lixin Ma;Yuan Wang(State Key Laboratory of Biocatalysis and Enzyme Engineering,School of Life Sciences,Hubei University,Wuhan 430062,Hubei,China;College of Medical,Hubei University of Arts and Science,Xiangyang 441053,Hubei,China;Hubei Key Laboratory of Edible Wild Plants Conservation and Utilization,Hubei Normal University,Huangshi 435002,Hubei,China;School of Life Sciences and Technology,Wuhan University of Bioengineering,Wuhan 430415,Hubei,China)

机构地区：[1]湖北大学生命科学学院,省部共建生物催化与酶工程国家重点实验室,湖北武汉430062 [2]湖北文理学院医学院,湖北襄阳441053 [3]湖北师范大学生命科学学院,食用野生植物保育与利用湖北省重点实验室,湖北黄石435002 [4]武汉生物工程学院生命科学与技术学院,湖北武汉430415

出　　处：《生物工程学报》2020年第5期879-890,共12页Chinese Journal of Biotechnology

基　　金：襄阳市科技研究与开发项目(襄科计)(No.2017-32);湖北省自然科学基金(Nos.2017CFB241,2015CFB605);湖北文理学院教师培育基金(No.2017kypy008);中国博士后面上项目(No.2019M650176)资助

摘　　要：人细小病毒B19(Human parvovirus B19,简称B19病毒),是目前为止已知能够感染并引起人类疾病的两种细小病毒科成员之一。B19病毒作为一种重要病原,能够引起如儿童传染性红斑、急性再障危象、胎儿水肿甚至死胎等疾病。文中从B19病毒基因型、病毒受体、基因组结构特点与复制、病毒转录与转录后调控、病毒非结构和结构蛋白特点与功能以及病毒诊断及抗病毒药物研究策略6个方面来综述B19病毒的最新研究进展,以期为B19病毒致病机制的深入研究与治疗诊断策略的制定提供参考。Human parvovirus B19(B19 virus)is one of the two parvoviruses that cause human diseases.As an important pathogen to humans,it causes infectious erythema in children,acute aplastic anemia,fetal edema and death.In this review,we focus on the recent advances in the molecular virology of B19V,such as viral genotypes,viral receptor,genomic features and viral replication,viral transcription and post-transcription regulation,viral nonstructural and structural protein features and functions,viral diagnosis and antiviral agents,to provide reference for further study of B19 pathogenesis mechanisms,treatment and diagnostic strategies.

关 键 词：B19病毒 基因型 基因组特点 转录与转录后调控 病毒蛋白特点与功能 病毒诊断和抗病毒药物 

分 类 号：R373[医药卫生—病原生物学]