大型真菌来源含氮杂环化合物的结构及生物活性研究进展  

Research Progresses on Chemical Structure and Bioactivity of Natural Nitrogen Heterocycles in Macrofungi

作　　者：吴莹莹 高利慧[1,2] 康前进 鲍大鹏[1,2] 王莹[2] WU Yingying;GAO Lihui;KANG Qianjin;BAO Dapeng;WANG Ying(College of Food Science&Technology,Shanghai Ocean University,Shanghai 201306,China;Institute of Edible Fungi,Shanghai Academy of Edible,National Engineering Research Center of Edible Fungi Key Laboratory of Edible Fungi Resources and Utilization(South),Ministry of Agriculture and Rural Affairs,P.R.China,National R&D Center for Edible Fungi Processing,Key Laboratory of Agricultural Genetics and Breeding of Shanghai,Shanghai 201403,China;State Key Laboratory of Microbial Metabolism,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]上海海洋大学食品学院,上海201306 [2]上海市农业科学院食用菌研究所,国家食用菌工程技术研究中心,农业农村部南方食用菌资源利用重点实验室,上海201403 [3]上海交通大学生命科学技术学院,微生物代谢国家重点实验室,上海200240

出　　处：《食用菌学报》2020年第2期120-138,共19页Acta Edulis Fungi

基　　金：上海市科委国际科技合作基金项目(18390741000);上海市现代农业产业技术体系项目[沪农科产字(2020)第9号];上海市农业科学院卓越团队建设计划[农科创2017(A-06)]。

摘　　要：大型真菌不仅具有较高的营养价值和药用价值,而且是天然活性产物的重要来源,其中许多种类有着广阔的开发应用前景。含氮杂环化合物是天然产物的一个重要家族,目前已有多种分离自大型真菌的含氮杂环化合物被证明具有显著的生物活性。对近十年来文献报道的大型真菌来源含氮杂环化合物(吲哚类、吡啶类、吡咯类、核苷类和环肽类)的化学结构及生物活性进行了系统的总结,以期为开发高附加值的大型真菌品种及其深加工产品,深入发掘大型真菌来源的天然药物提供参考。Macrofungi not only have high nutritional and medicinal values, but also are important sources of bioactive natural compounds, many of which have broad prospects for development and application. Nitrogen heterocyclic compounds are an important family of natural products. At present, many nitrogen heterocyclic compounds isolated from macrofungi have significant biological activities. Advances of recent 10 years in chemical structures and bioactivities of macrofungi-derived nitrogen heterocyclic compounds, including indoles, pyridines, pyrroles, nucleosides and cyclopeptides, were reviewed and discussed in this article.

关 键 词：食用菌 药用菌 裸盖菇素 吲哚 吡啶 吡咯 核苷 环肽 

分 类 号：Q936[生物学—微生物学]