依沙吖啶联合米非司酮治疗中期妊娠引产的临床研究  

Clinical study of ethacridine combined with mifepristone in treatment of midtrimester induction of labor

作　　者：魏晓存 许雅娟[1] 王梦琦[1] WEI Xiaocun;XU Yajuan;WANG Mengqi(Department of Obstetrics,Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院产科,河南郑州450052

出　　处：《药物评价研究》2020年第5期916-919,972,共5页Drug Evaluation Research

基　　金：河南省医学科技攻关计划项目(201403110)。

摘　　要：目的探讨依沙吖啶联合米非司酮在中期妊娠引产治疗中的临床疗效。方法选取郑州大学第三附属医院2015年1月-2019年6月产科220例中期妊娠引产患者为研究对象。根据治疗方法将患者分为对照组(80例)和观察组(140例)。对照组先口服米非司酮片,50 mg/次,2次/d,连续服用2 d后将米索前列醇片置于阴道穹窿处,妊娠24周以内400μg/次,3 h重复,但不超过1.8 mg;妊娠24周以上200μg/次,6 h可重复,每日给药不超过4次。观察组患者口服米非司酮片(用法同对照组)后1 h采用7号穿刺针于下腹正中、宫底下两三横指下方腹中线上进行羊膜腔穿刺,注入100 mg乳酸依沙吖啶注射液。比较两组患者的引产效果、手术情况、疼痛程度、月经恢复以及不良反应发生情况。结果治疗后,观察组患者引产成功率与清宫率分别为98.57%与19.29%,对照组患者引产成功率与清宫率分别为85.00%与35.00%,两组比较存在统计学差异(P<0.05)。与对照组相比,观察组患者的产后2 h出血量、用药至规律宫缩时间、规律宫缩至胎儿娩出时间、产后出血时间及胎盘残留率更少(P<0.05)。治疗后,观察组患者1分疼痛的比率显著高于对照组(P<0.05)。两组患者月经复潮时间及经期持续时间比较无统计学差异。治疗期间,观察组和对照组不良反应发生率分别为8.57%、17.50%,两组比较无统计学差异。结论依沙吖啶联合米非司酮可有效提高引产效果,引产时间短,产后恢复快,安全性高,在中期妊娠引产患者中具有较高的应用价值。Objective To investigate the efficacy of ethacridine combined with mifepristone in treatment of midtrimester induction of labor.Methods Patients(220 cases)with midtrimester induction of labor in the Third Affiliated Hospital of Zhengzhou University from January 2015 to June 2019 were divided into control group(n=80)and observation group(n=140)according to the treatment method.Patients in the control group was po administered with Mifepristone Tablets,50 mg/time,twice daily.After continuous administration of Mifepristone Tablets for 2 days,Misoprostol Tablets were placed on the vaginal fornix.Patients within24 weeks of pregnancy were treated for 400μg/time,3 hours of repetition,but not more than 1.8 mg,Patients more than 24 weeks of pregnancy were 200μg/time for 6 hours of repetition,no more than four times daily.Patients in the observation group were po administered with Mifepristone Tablets(the same as the control group).After1 hour of oral administration,amniocentesis was performed with no.7 needle in the middle of the lower abdomen and the abdominal midline below the two or three fingers of the uterus,and injected with 100 mg Ethacridine Lactate Injection.The induced labor effect,operation condition,pain severity,menstrual recovery,and adverse reactions in two groups were compared.Results After treatment,the success rate of induced labor and the rate of curettage were 98.57%and 19.29%in the observation group,and 85.00%and 35.00%in the control group,respectively,there was statistical difference between the two groups(P<0.05).Compared with the control group,patients in the observation group had less bleeding volume in 2 h after delivery,the time from administration to regular uterine contraction,time from regular uterine contraction to fetal delivery,time of postpartum hemorrhage,and placenta residual rate(P<0.05).After treatment,the rate of 1 point pain in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference in the menstruation time and dura

关 键 词：依沙吖啶 米非司酮 米索前列醇 中期妊娠引产 引产成功率 不良反应 

分 类 号：R984[医药卫生—药品]