加味小柴胡汤治疗咳嗽变异性哮喘的临床疗效观察  

Clinical Study and Analysis of Modified Xiaochaihu Decoction in Treating Cough Caused by Variant Asthma

作　　者：张文钊[1] 田洪昭[1] 张丽娇 杨善军[2] ZHANG Wen-zhao;TIAN Hong-zhao;ZHANG Li-jiao;YANG Shan-jun(Heilongjiang University of Traditional Chinese Medicine,Harbin Heilongjiang 150040;Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin Heilongjiang 150000)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150000

出　　处：《世界中西医结合杂志》2020年第5期790-793,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：2017年哈尔滨市应用技术研究与开发项目(青年后备人才)(2017RAQXJ189)。

摘　　要：目的探讨加味小柴胡汤治疗咳嗽变异性哮喘(CVA)的临床疗效。方法收集2014年9月—2018年12月在黑龙江中医药大学附属第二医院呼吸内科治疗的CVA患者897例,分为对照组(368例)和观察组(529例),分别接受常规西药治疗和加味小柴胡汤联合常规西药治疗。治疗后评估和比较两组患者在治疗1、3、5和7周后的白天和夜间症状评分、疾病控制情况、支气管扩张剂使用情况、症状的改善情况及不良反应发生情况。结果治疗后1、3、5和7周,观察组咳嗽症状总评分、日间症状评分以及夜间症状评分均明显低于对照组(P<0.05)。治疗后1、3、5和7周,观察组疾病控制率均明显高于对照组(P<0.05)。治疗后1、3、5和7周,观察组中医症状积分均明显低于对照组(P<0.05)。两组患者均没有发生与药物有关的严重不良事件发生。结论对于CVA采用加味小柴胡汤联合西药治疗,效果较为理想,安全性较高,值得在临床推广应用。Objective The purpose of this study was to investigate the clinical effect of Jiawei Xiaochaihu Decoction on asthma caused by variant asthma.Methods This study included 897 patients with cough variant asthma(CVA)treated with respiratory medicine in the Department of Respiratory Medicine of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from September 2014 to December 2018.,Those patients were divided into a control group(n=368)and an observation group(n=529),receiving conventional Western medicine treatment and Jiawei Xiaochaihu Decoction combined with conventional western medicine treatment,to evaluate and compare the daytime and nocturnal symptom scores,disease control status,and bronchodilators use of the two groups of patients after 1,3,5,and 7 weeks of treatment.The improvements of symptoms and the occurrence of adverse reactions.Results At 1,3,5,and 7 weeks after treatment,the total cough symptom score,daytime symptom score,and night symptom score were significantly lower in the observation group than those of the control group(P<0.05).At 1,3,5 and 7 weeks after treatment,the disease control rate of the observation group was significantly higher than that of the control group(P<0.05).At 1,3,5,and 7 weeks after treatment,the scores of TCM symptoms in the observation group were significantly lower than those in the control group(both p P<0.05).There were no serious adverse events related to the drug in both groups.Conclusions For the treatment of cough variant asthma,Jiawei Xiaochaihu Decoction combined with Western medicine is more effective and safe.,which is worthy of clinical application.

关 键 词：加味小柴胡汤 咳嗽变异性哮喘 西药治疗 

分 类 号：R725.6[医药卫生—儿科]