虫草制剂联合血管紧张素受体阻滞剂治疗糖尿病肾病的Meta分析  

Cordyceps Preparation Combined with Angiotensin Receptor Blocker in Treating Diabetic Nephropathy:Meta Analysis

作　　者：刘丹丹[1] 王祥生[1] 王建明[1] 杜纪鸣 LIU Dan-dan;WANG Xiang-sheng;WANG Jian-ming;DU Ji-ming(Jining City Traditional Chinese Medicine Hospital,Jining Shandong 272000)

机构地区：[1]济宁市中医院,山东济宁272000

出　　处：《世界中西医结合杂志》2020年第5期835-840,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：山东省名中医药专家传承工作室项目——“杜纪鸣全省名中医药专家传承工作室”。

摘　　要：目的系统评价虫草制剂联合血管紧张素受体阻滞剂治疗糖尿病肾病的疗效。方法检索PubMed、中国知网(CNKI)、维普(VIP)、万方医学网(1997年—2018年2月)中虫草制剂联合血管紧张素受体阻滞剂治疗糖尿病肾病的随机对照试验进行Meta分析。结果共纳入53项研究,4010例患者。联合用药试验组可显著降低糖尿病肾病患者的24 h尿蛋白[P<0.00001;MD=-0.23(-0.28,-0.17)g/24 h;17项研究718例患者],尿微量白蛋白排泄率[P<0.00001;MD=-23.83(-28.19,-19.47)μg/min;33项研究1228例患者],血肌酐[P<0.00001;MD=-9.11(-12.75,-5.46)μmol/L;40项研究1529例患者]及尿素氮[P<0.00001;MD=-0.77(-1.06,-0.49)mmol/L;24项研究928例患者]。结论虫草制剂联合血管紧张素受体阻滞剂可明显降低糖尿病肾病患者的尿蛋白及改善肾功能,但因为研究分析的局限性及纳入文献的低质量性,尚需要更多高质量多中心大样本及长期随访的随机对照试验提供更优质的循证医学依据。Objective To systematically evaluate the efficacy of Cordyceps preparation combined with angiotensin receptor blocker in the treatment of diabetic nephropathy.Methods PubMed,CNKI,VIP and Wanfang Medical Network(February 2018)were retrieved,and randomized controlled trials of Cordyceps preparation combined with angiotensin receptor blocker in the treatment of diabetic nephropathy were included and meta-analyzed.Results A total of 4010 patients were enrolled in 53 studies.The 24-hour urinary protein[P<0.00001;MD=-0.23(-0.28,-0.17)g/24 h;17 studies 718 patients],urinary microalbumin excretion rate[P<0.00001;MD=-26.32(-27.32,-25.33)μg/min;33 studies 1258 patients],serum creatinine[P<0.00001;MD=-8.47(-9.15,-7.78)μmol/L;40 studies 29 patients[P<0.00001;and urea nitrogen]MD=-1.27(-1.33,-1.21)mmol/L;24 studies 928 patients].Conclusions Cordyceps preparation combined with angiotensin receptor blockers(ARB)can significantly reduce urinary protein and improve renal function in DN patients.

关 键 词：虫草制剂 血管紧张素受体阻滞剂 糖尿病肾病 META分析 

分 类 号：R473.5[医药卫生—护理学]