N-氨基酰基甲脒类化合物的合成研究  

Synthesis of N-Aminoacyl Formamidines

作　　者：张磊 张艳慧[1] 阿不都热合曼·乌斯曼[1] ZHANG Lei;ZHANG Yanhui;WUSIMAN Abudureheman(School of Chemistry and Chemical Engineering,Xinjiang Normal University,Urumqi 830054,China)

机构地区：[1]新疆师范大学化学化工学院,新疆乌鲁木齐830054

出　　处：《化学与生物工程》2020年第5期1-5,共5页Chemistry & Bioengineering

基　　金：国家自然科学基金项目(21762044);新疆师范大学“十三五”校级重点学科化学资助项目。

摘　　要：以N-取代脲和甲酰胺为原料,合成了一系列N-氨基酰基甲脒类化合物,讨论了活化剂、溶剂、反应温度及底物投料比对反应的影响。结果表明,以草酰氯为活化剂、二氯甲烷为溶剂,在n(N-取代脲)∶n(甲酰胺)∶n(草酰氯)为1.0∶1.5∶1.2时,室温反应1~4 h可得到产率高达98%的目标化合物。该方法具有底物范围广、操作简便、反应条件温和、反应时间短、产率高等优点。Using N-substituted ureas and formamides as raw materials,we synthesized a series of N-aminoacyl formamidines.Moreover,we investigated the effects of activating reagent,solvent,reaction temperature,and reactant molar ratio on the reaction.The results show that the target compound with the yield of 98%is obtained at room temperature for 1~4 h under the optimum conditions as follows:using oxalyl chloride as the activating reagent,and dichloromethane as the solvent,the molar ratio of N-substituted urea,formamide,and oxalyl chloride is 1.0∶1.5∶1.2.This method has the advantages of wide range of substrates,simple operation,mild reaction conditions,short reaction time,and high yield.

关 键 词：N-酰基脒 N-取代脲 N-氨基酰基甲脒 草酰氯 

分 类 号：O626[理学—有机化学]