阿胶强骨口服液连续逆流提取工艺研究  

Continuous Countercurrent Extraction Process of Ejiao Qianggu Oral Liquid

作　　者：古孜丽阿依·库尔班 黄卉 陈伟 朱倩兰 武嘉林 KUERBAN Guziliayi;HUANG Hui;CHEN Wei;ZHU Qianlan;WU Jialin(College of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830011,China;Xinjiang Huashidan Pharmaceutical Co. ,Ltd. ,Urumqi 830011,China;Xinjiang Huashidan Pharmaceutical Research Co. ,Ltd. ,Urumqi 830011,China)

机构地区：[1]新疆医科大学中医学院,新疆乌鲁木齐830011 [2]新疆华世丹药业股份有限公司,新疆乌鲁木齐830011 [3]新疆华世丹药物研究有限责任公司,新疆乌鲁木齐830011

出　　处：《化学与生物工程》2020年第5期46-51,共6页Chemistry & Bioengineering

基　　金：兵团专利运用及产业化项目(2018BD002)。

摘　　要：以毛蕊花糖苷、毛蕊异黄酮葡萄糖苷、黄芪甲苷、总多糖含量和提取率为考察指标,采用多指标综合评分法结合正交实验,优化阿胶强骨口服液连续逆流提取工艺。结果表明,4个因素对提取效果的影响大小依次为:提取温度>提取时间>乙醇体积分数>料液比,确定最佳提取工艺为:料液比1∶6(g∶mL)、乙醇体积分数40%、提取时间120 min、提取温度80℃。优选的连续逆流提取工艺高效、节能,适合于阿胶强骨口服液工业化生产,为阿胶强骨口服液生产工艺相关研究提供了科学依据。Using the contents of verbascoside,calycosin-7-O-β-D-glucopyranoside,astragaloside,total polysaccharide and the extract yield as indexes,we optimized the continuous countercurrent extraction process of Ejiao Qianggu Oral Liquid by multi-index comprehensive evaluation method and orthogonal experiments.The results show that the influence of four factors on extraction effect is as follows:extraction temperature>extraction time>ethanol volume fraction>solid-liquid ratio.The optimum extraction process is determined as follows:the solid-liquid ratio of 1∶6(g∶mL),the ethanol volume fraction of 40%,the extraction time of 120 min,and the extraction temperature of 80℃.The optimized continuous countercurrent extraction process has the advantages of high efficiency and energy saving,which is suitable for the industrial production of Ejiao Qianggu Oral Liquid and provides scientific basis for the related research on the production process of Ejiao Qianggu Oral Liquid.

关 键 词：阿胶强骨口服液 连续逆流提取 毛蕊花糖苷 毛蕊异黄酮葡萄糖苷 黄芪甲苷 

分 类 号：R284.2[医药卫生—中药学]