癃清片治疗慢性前列腺炎的临床疗效及安全性的Meta分析  

Meta-analysis of Clinical Therapeutic Effects and Safety of Longqing Tablets in the Treatment of Chronic Prostatitis

作　　者：汪绪祥 王锁刚[2] 陈铸[2] 崔勇[2] 翟琼瑶 王帝[2] 王光策[2] WANG Xuxiang;WANG Suogang;CHEN Zhu;CUI Yong;ZHAI Qiongyao;WANG Di;WANG Guangce(Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Urology,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,郑州450046 [2]河南中医药大学第一附属医院泌尿外科,郑州450000

出　　处：《世界中医药》2020年第10期1423-1428,共6页World Chinese Medicine

基　　金：河南省高等学校重点科研计划项目(18A320001)。

摘　　要：目的:基于Meta分析方法,整体评价癃清片治疗不同类型慢性前列腺炎的临床疗效及安全性,为临床合理药物治疗提供循证医学证据。方法:依据检索策略,以主题词加自由词的方法,通过计算机检索中英文数据库The Cochrane Library、Web of science、PubMed、Embase、ProQuest、中国生物医学文摘数据库、中国知网、万方和维普,时间设置为从建库开始至2019年8月;结合手工搜索近些年主流中英文杂志。通过软件查重、标题筛选、摘要筛选、文章内容筛选获取最终文献。结果:最终纳入12篇随机对比文献,共2621例患者。Meta分析2组患者总有效率:[RR=1.42,95%CI(1.20,1.68),P<0.0001];2组患者NIH-CPSI评分:[MD=-4.81,95%CI(-7.00,-2.61),P<0.0001];2组患者前列腺按摩液(EPS)中白细胞计数:[MD=-1.31,95%CI(-2.05,-0.58),P=0.0004];2组患者不良反应发生率:[RR=0.81,95%CI(0.31,2.08),P=0.65]。结论:癃清片在慢性前列腺炎的治疗中具有显著效果,与对照组比较,观察组NIH-CPSI评分、EPS白细胞计数明显下降,且无严重不良反应。selection and paper content selection.Results:A total of 12 randomized controlled literature were finally included,with 2621 patients.Meta-analysis showed that the total effective rate of the 2 groups of patients was as follows:[RR=1.42,95%CI(1.20,1.68),P<0.0001];NIH-CPSI scores of the 2 groups:[MD=-4.81,95%CI(-7.00,-2.61),P<0.0001];White blood cell count in prostatic massage fluid(EPS)of the 2 groups:[MD=-1.31,95%CI(-2.05,-0.58),P=0.0004];Adverse reactions incidence rate of the 2 groups:[RR=0.81,95%CI(0.31,2.08),P=0.65].Conclusion:The Longqing Tablets has significant effects in the treatment of chronic prostatitis.Compared with the control group,the NIH-CPSI score and EPS white blood cell count in the treatment group decreased significantly,and there were no serious adverse reactions.

关 键 词：癃清片 慢性前列腺炎 合理用药 循证医学 META分析 

分 类 号：R277.5[医药卫生—中医学]