电针治疗阿尔茨海默病的β-淀粉样蛋白沉积相关机制研究进展  

Mechanisms of electroacupuncture for improving Alzheimer’s disease from reducingβamyloid protein level

作　　者：杨文丹 董卫国[2] YANG Wen-dan;DONG Wei-guo(College of Acupuncture and Moxibustion,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;College of Integrated Chinese and Western Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]福建中医药大学针灸学院,福州350122 [2]福建中医药大学中西医结合学院,福州350122

出　　处：《针刺研究》2020年第5期426-430,F0003,共6页Acupuncture Research

基　　金：福建省卫生计生中青年骨干人才培养项目(No.2017-ZQN-63);福建省自然科学基金项目(No.2017J01541);福建省中医药科研项目(No.2017FJZYJC102);福建省科技厅科技平台建设项目(No.2015Y2001-64)。

摘　　要：阿尔茨海默病(AD)属于最常见的痴呆疾病,电针疗法现已被广泛运用于AD的临床治疗,并取得较满意的疗效。本文主要从β-淀粉样蛋白生成与清除角度阐释电针治疗AD的作用机制,其中涉及自噬、氧化应激与能量代谢、炎性反应等相关机制,并展望一种综合的临床AD防治方案。Alzheimer’s disease(AD),a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary degeneration,is the most common type of dementia and has no incurable therapies at the moment.Electroacupuncture(EA)therapy has been widely used in clinical treatment of AD,and has attained approving effects.This article reviews the development of researches on the mechanisms of EA underlying improving AD by diminishingβamyloid protein(Aβ)neurotoxicity,from 1)up-regulating hippocampal cellular autophagy,2)improving cerebral energy metabolism by activating oxidation stress-related factors peroxisome proliferator-activated receptorγcoactivator 1 alpha and sirtuin 1 in the hippocampus and frontal cerebral cortex,3)relieving inflammatory reaction by lowering expression of tumor necrosis factor-alpha and high-mobility group box 1 and increasing expression of Interleukin 10,and 4)promoting degradation of Aβ1-42 by down-regulating expression of insulin degeneration enzyme,lipoprotein,transthyretin,apolipoprotein andα2 mcroglobulin.Meanwhile,a comprehensive clinical therapy of AD is proposed.

关 键 词：电针 阿尔茨海默病 Β-淀粉样蛋白 机制研究 

分 类 号：R245.97[医药卫生—针灸推拿学]