广州口岸入境外籍人员黄热病毒核酸及抗体水平分析  

Analysis of Nucleic Aid and Antibody Levels of Yellow Fever Virus in Entry Foreigners at Guangzhou Port

作　　者：张建明 梁蓉蓉 颜杰 吴健 陈嘉 苏锦坤 涂苏林 Zhang Jianming;Liang Rongrong;Yan Jie;Wu Jian;Chen Jia;Su Jinkun;Tu Sulin(Guangzhou International Travel Health Care Center,Guangzhou,Guangdong,510635)

机构地区：[1]广州国际旅行卫生保健中心,广东广州510635

出　　处：《口岸卫生控制》2020年第1期53-57,共5页Port Health Control

基　　金：国家质检总局科技计划项目(2017Ik122)。

摘　　要：目的了解广州口岸入境外籍人员中黄热病毒核酸及该人群黄热病毒抗体水平,为研究黄热病输入我国的风险及口岸黄热病防控工作提供依据。方法对来自黄热病高风险区,离开高风险区<6天,无症状且未能出示黄热病疫苗接种记录的外籍人,开展流行病学调查,进行黄热病毒核酸、抗体检测及数据分析。结果在2017-2019年间,结合流行病学调查随机抽选共839份目标人群的血清样本列入研究组,用荧光定量PCR法进行黄热病毒核酸检测,结果均为阴性;同时使用间接免疫荧光法(IFA)进行黄热病毒抗体IgG检测,结果显示阳性率为56.73%。其中年龄、人员类别和来源国是IgG抗体阳性率的影响因素。结论我国存在黄热病输入风险,对来自黄热病高风险区的人员开展黄热病毒核酸及抗体检测有助于口岸黄热病的防控工作;来自黄热病高风险区的外籍人员,黄热病毒抗体阳性率随年龄增加而升高。Object To understand the nucleic acid and antibody level of yellow fever virus in entry foreigners at Guangzhou port,so as to provide basis for the study of the imported risk of yellow fever and the Prevention and control measures at the ports of China.Methods The study was carried out on the foreigners who came from the yellow fever high risk areas(the duration of departure from high risk area is less than 6 days),without symptoms and yellow fever vaccination record.Epidemiological investigation,the detection of nucleic acid and antibody and data analysis were implemented.Results During 2017-2019,a total of 839 serum samples from the target persons were randomly selected.All of the samples were negative of yellow fever virus nucleic aid by fluorescent quantitative PCR;meanwhile,the IgG was detected by IFA,and the positive rate was 56.73%.Age,type of personnel and country of origin are the influence factors of IgG antibody positive rate.Conclusion There’s imported risk of yellow fever in China.The detection of viral nucleic acids and antibodies for persons from yellow fever high risk areas is contributed to the prevention and control the importation of yellow fever at ports.The positive rate of yellow fever antibodies increases with age for foreigners from high risk areas of yellow fever.

关 键 词：黄热病 黄热病毒核酸 黄热病毒抗体 

分 类 号：R183.5[医药卫生—流行病学]