Vascular depression for radiology: A review of the construct,methodology,and diagnosis  

作　　者：Sara N Rushia Al Amira Safa Shehab Jeffrey N Motter Dakota A Egglefield Sophie Schiff Joel R Sneed Ernst Garcon 

机构地区：[1]Department of Psychology,The Graduate Center,City University of New York,New York,NY 10016,United States [2]Department of Psychology,Queens College,City University of New York,Queens,NY 11367,United States [3]Division of Geriatric Psychiatry,New York State Psychiatric Institute,New York,NY 10032,United States [4]Department of Psychiatry,Columbia University Medical Center,New York,NY 10032,United States [5]Department of Radiology,Columbia University Medical Center,New York,NY 10032,United States

出　　处：《World Journal of Radiology》2020年第5期48-67,共20页世界放射学杂志（英文版）（电子版）

摘　　要：Vascular depression(VD)as defined by magnetic resonance imaging(MRI)has been proposed as a unique subtype of late-life depression.The VD hypothesis posits that cerebrovascular disease,as characterized by the presence of MRIdefined white matter hyperintensities,contributes to and increases the risk for depression in older adults.VD is also accompanied by cognitive impairment and poor antidepressant treatment response.The VD diagnosis relies on MRI findings and yet this clinical entity is largely unfamiliar to neuroradiologists and is rarely,if ever,discussed in radiology journals.The primary purpose of this review is to introduce the MRI-defined VD construct to the neuroradiology community.Case reports are highlighted in order to illustrate the profile of VD in terms of radiological,clinical,and neuropsychological findings.A secondary purpose is to elucidate and elaborate on the measurement of cerebrovascular disease through visual rating scales and semi-and fully-automated volumetric methods.These methods are crucial for determining whether lesion burden or lesion severity is the dominant pathological contributor to VD.Additionally,these rating methods have implications for the growing field of computer assisted diagnosis.Since VD has been found to have a profile that is distinct from other types of late-life depression,neuroradiologists,in conjunction with psychiatrists and psychologists,should consider VD in diagnosis and treatment planning.

关 键 词：Vascular depression DEPRESSION Magnetic resonance imaging Cerebrovascular disorders White matter hyperintensities NEURORADIOLOGY Case reports 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.4[医药卫生—诊断学]