丙肝病毒核心抗原检测的临床价值及其与HCV-RNA、ALT、AST的关系研究  

Clinical Value of HCV-cAg Detection and Its Relationship with HCV-RNA,ALT and AST

作　　者：刘英超[1] 张秋月 刘琳 任更朴[1] LIU Ying-chao;ZHANG Qiu-yue;LIU Lin(Department of Clinical Laboratory,The Second People's Hospital of Liaocheng,Liaocheng,The Second Hospital of Liaocheng affiliated to Shandong First Medical University,Shandong 252600)

机构地区：[1]聊城市第二人民医院,山东第一医科大学附属聊城二院检验科,252600

出　　处：《临床输血与检验》2020年第3期316-318,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的 探讨丙肝病毒核心抗原(HCV-cAg)检测的临床价值及其与HCV-RNA、ALT、AST的关系。方法 留取112例HCV-cAg检测阳性标本,205例丙肝病毒核心抗体(HCV-Ab)阳性标本,利用实时定量PCR法测定HCV-RNA,同时进行肝功能(ALT、AST)检测。结果 112例HCV-cAg阳性和205例HCV-Ab阳性标本中,HCV-RNA阳性分别为95例(阳性率84.8%)和142例(阳性率69.3%),前者显著高于后者(P<0.05);前者肝功能异常70例(占62.5%),后者肝功能异常95例(占46.3%),前者显著高于后者(P<0.05)。HCV-cAg结果S/CO值增高与HCV-RNA 阳性率和肝功能异常率呈正相关。结论 HCV-cAg检测阳性结果与HCV-RNA符合率高,并能够反应肝功能损伤程度,HCV-cAg检测对辅助临床诊疗具有重要的价值。Objective To investigate the clinical value of detection of HCV-cAg and its relationship with HCVRNA,ALT and AST.Methods 112 HCV-cAg positive specimens and 205 HCV-Ab positive specimens were collected.Realtime Quantitative PCR method was used to detect HCV-RNA,and at the same time liver function(ALT,AST)was detected.Results There were 95 HCV-RNA-positive cases from the 112 HCV-cAg positive specimens(a positive rate of 84.8%)and 142 HCV-RNA-positive cases from 205 HCV-Ab positive specimens(a positive rate of 69.3%),respectively,and therewas significantly higher HCV RNA positive rate in the former than that in the latter(P<0.05);The former had 70 cases of abnormal liver function(62.5%)and the latter 95 cases(46.3%).The former was significantly higher than that of the latter(P<0.05).The increase of the value of S/CO in HCV-cAg results was positively correlated with the positive rate of HCV-RNA and the abnormal rate of liver function.Conclusion The positive results of HCV-cAg test highly correlate to HCV-RNA,and reflect the status of liver function.HCV-Ag test has important value in assisted clinical diagnosis.

关 键 词：丙型肝炎 丙肝病毒核心抗原 丙肝病毒核心抗体 丙肝病毒RNA 肝功能 

分 类 号：R446.62[医药卫生—诊断学]