热敏灸辅助治疗中度肝癌痛的疗效及对TNF-a、IL-2的影响  

Therapeutic Efficacy of Heat-sensitive Moxibustion in Adjuvant Treatment of Moderate Liver Cancer Pain and Its Effects on TNF-aand IL-2

作　　者：刘丽霞[1] LIU Li-xia(Zhejiang Lishui Municipal Central Hospital,Lishui 323000,China)

机构地区：[1]浙江省丽水市中心医院,丽水323000

出　　处：《上海针灸杂志》2020年第6期692-696,共5页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的观察热敏灸辅助治疗中度肝癌痛的疗效及相关作用机制。方法将60例中度肝癌痛患者随机分为对照组和观察组,每组30例。对照组予盐酸曲马多缓释片口服治疗,观察组在此基础上予热敏灸治疗,疗程为2周。治疗前后评定癌痛数字分级法(numeric rating scale, NRS)评分、24 h疼痛时间及睡眠时间、肝癌患者生存质量测定量表(quality of life scale for liver cancer, QOL-LC),于治疗结束后进行疗效评价。并于治疗前后测定患者血清肿瘤坏死因子-a(tumor necrosis factor-a, TNF-a)、白介素-2(interleukin-2, IL-2)水平。结果观察组治疗中度肝癌痛有效率明显高于对照组(P<0.05);两组治疗后NRS评分、24 h疼痛时间及睡眠时间疼痛相关指标均明显改善(P<0.05),且观察组优于对照组(P<0.05);两组治疗后QOL-LC评分明显提升(P<0.05),且观察组高于对照组(P<0.05);观察组治疗后血清TNF-a、IL-2水平明显改善(P<0.05)。结论热敏灸辅助治疗中度肝癌痛的疗效确切,能明显改善患者NRS评分,减少疼痛时间,促进睡眠,改善患者生存质量,这可能与其调整TNF-a、IL-2水平相关。Objective To observe the therapeutic efficacy of heat-sensitive moxibustion in adjuvant treatment of moderate cancer pain and the relevant action mechanism.Method Sixty patients with moderate liver cancer pain were randomized into a control group and an observation group,with 30 cases in each group.The control group was given Tramadol hydrochloride tablets for treatment,based on which the observation group was intervened by heat-sensitive moxibustion.The treatment course was 2 weeks.The Numeric Rating Scale(NRS),24-h pain duration and sleep duration,and Quality of Life Scale for Liver Cancer(QOL-LC)were assessed before and after treatment.The therapeutic efficacy was evaluated after treatment.The levels of tumor necrosis factor-a(TNF-a)and interleukin-2(IL-2)in serum of the patients were detected before and after treatment.Result The effective rate in treating moderate liver cancer pain was significantly higher in the observation group than in the control group(P<0.05);after treatment,the pain-related indexes including NRS score,24-h pain duration and sleep duration showed significant improvements in both groups(P<0.05),and were better in the observation group than in the control group(P<0.05);the QOL-LC score increased significantly after treatment in both groups,and was higher in the observation group than in the control group(P<0.05);the levels of TNF-aand IL-2 showed marked improvements after treatment in the observation group(P<0.05).Conclusion Heat-sensitive moxibustion is effective in adjuvant treatment of moderate liver cancer pain;it can notably improve the NRS score,shorten pain duration,promote sleep and enhance the quality of life,which may be associated with its regulation of TNF-aand IL-2 levels.

关 键 词：灸法 艾条灸 热敏灸 癌痛 肿瘤坏死因子-A 白介素-2 肝癌患者生存质量测定量表 癌痛数字分级法 

分 类 号：R246.5[医药卫生—针灸推拿学]