冠状静脉向动脉转化的研究进展  

Research progress of coronary vein to arterial transformation

作　　者：谭兰兰 武晓静 周骐[3] TAN Lanlan;WU Xiaojing;ZHOU Qi(Chongqing Medical University,Chongqing 400000,China;Department of Cardiology,Shenzhen University General Hospital,Shenzhen,Guangdong 518000,China;Department of Cardiology,the Second Affliated Hospital of Chongqing Medical University,Chongqing 400000,China)

机构地区：[1]重庆医科大学,重庆市400000 [2]深圳大学总医院心血管内科,广东省深圳市518000 [3]重庆医科大学附属第二医院心血管内科,重庆市400000

出　　处：《中国动脉硬化杂志》2020年第6期544-547,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81370404)。

摘　　要：冠状动脉粥样硬化性心脏病(CHD)病理特征为不稳定粥样硬化斑块破裂或糜烂基础上血小板聚集、并发血栓形成、冠状动脉痉挛收缩、微血管栓塞导致急性或亚急性心肌供氧的减少和缺血加重,有研究表明冠状静脉可向冠状动脉转化。本文综述了血管生成的分类、冠状静脉向动脉转化的过程、冠状静脉向动脉转化的临床意义和潜在治疗靶点的探索,为今后冠状动脉再生提供治疗依据。The pathological characteristic of coronary heart disease(CHD)is rupture or erosion of atherosclerotic plaques of coronary artery which induces platelet aggregation, thrombosis, coronary artery spasm,microvascular embolism.They cause acute or subacute hypoxia or ischemia of myocardium. Studies show that coronary arterial endothelial cells can differentiate from venous endothelial cells. This review illustrates the classification of angiogenesis, the process of differentiation and clinical significance of coronary venous endothelial cells to arterial endothelial cells and the exploration of potential therapeutic targets. It aimed at providing reference for the future coronary angiogenesis.

关 键 词：静脉内皮细胞 动脉内皮细胞 血管分化 心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]