不同剂量辛伐他汀治疗老年高血压合并高脂血症的临床疗效及安全性分析  

Analysis of clinical efficacy and safety of different doses of simvastatin in the treatment of elderly hypertension with hyperlipidemia

作　　者：王庆月 WANG Qing-yue(Department of Pharmacy,Yanggu County People’s Hospital,Liaocheng 252300,China)

机构地区：[1]阳谷县人民医院药剂科,252300

出　　处：《中国实用医药》2020年第13期21-23,共3页China Practical Medicine

摘　　要：目的分析不同剂量辛伐他汀治疗老年高血压合并高脂血症的临床疗效和安全性。方法124例老年高血压合并高脂血症患者,按照用药剂量不同分为治疗A组与治疗B组,各62例。治疗A组应用大剂量辛伐他汀治疗,治疗B组应用低剂量辛伐他汀治疗。比较两组治疗前后血脂指标、肝功能指标临床疗效和安全性。结果治疗后,两组患者高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)及总胆固醇(TC)水平均较本组治疗前改善,且治疗A组患者HDL-C(1.60±1.05)mmol/L、LDL-C(3.85±0.83)mmol/L、TG(1.15±0.74)mmol/L及TC(4.52±1.23)mmol/L均优于治疗B组的(1.28±0.09)、(5.04±0.73)、(1.79±0.83)、(5.57±1.38)mmol/L,差异具有统计学意义(P<0.05)。治疗A组患者治疗总有效率95.16%高于治疗B组的82.26%,差异具有统计学意义(P<0.05)。两组患者治疗前后谷草转氨酶(AST)、谷丙转氨酶(ALT)、肌酸激酶(CK)水平组间比较,差异均无统计学意义(P>0.05)。治疗A组不良反应发生率8.06%与治疗B组的6.45%比较,差异无统计学意义(P>0.05)。结论老年高血压合并高脂血症患者更适合应用大剂量辛伐他汀,能够获得更佳的血脂调节效果和临床疗效,且能够保障用药安全性。Objective To analyze the clinical efficacy and safety of different doses of simvastatin in the treatment of elderly hypertension with hyperlipidemia.Methods A total of 124 elderly patients with hypertension with hyperlipidemia were divided into treatment group A and treatment group B by different drug doses,with 62 cases in each group.Treatment group A was treated by high-dose simvastatin,and treatment group B was treated by low-dose simvastatin.The blood lipid indicators and liver function indicators before and after treatment,clinical efficacy and safety were compared between the two groups.Results After treatment,the levels of high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglyceride(TG)and total cholesterol(TC)of the two groups were better than those before treatment of the same group,and HDL-C(1.60±1.05)mmol/L,LDL-C(3.85±0.83)mmol/L,TG(1.15±0.74)mmol/L and TC(4.52±1.23)mmol/L of treatment group A was better than those of treatment group B(1.28±0.09),(5.04±0.73),(1.79±0.83)and(5.57±1.38)mmol/L.The difference was statistically significant(P<0.05).The total effective rate of treatment 95.16%of treatment group A was higher than that of treatment group B 82.26%,and the difference was statistically significant(P<0.05).Before and after treatment,there was no statistically significant difference in levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),creatine kinase(CK)between the two groups(P>0.05).The incidence of adverse reactions of treatment group A was 8.06%,which had no statistically significant difference compared with that of treatment group B 6.45%(P>0.05).Conclusion Elderly patients with hypertension and hyperlipidemia are more suitable for high-dose simvastatin,which can obtain better blood lipid regulation effect and clinical efficacy,and can ensure the safety of medication.

关 键 词：高血压 高脂血症 辛伐他汀 大剂量 安全性 

分 类 号：R544.1[医药卫生—心血管疾病] R589.2[医药卫生—内科学]