Structural basis of a Tn7-like transposase recruitment and DNA loading to CRISPR-Cas surveillance complex  

作　　者：Beibei Wang Wenhao Xu Hui Yang 

机构地区：[1]State Key Laboratory of Molecular Biology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,Chino

出　　处：《Cell Research》2020年第2期185-187,共3页细胞研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(31971135)to H.Y.

摘　　要：Dear Editor,Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)and CRISPR-associated(Cas) systems confer RNA-guided adaptive immunity against invading genetic elements in prokar yotic cells.1 These system semploy CRISPR RNA(crRNA)containing surveillance complexes for sequence-specific recognition and degradation of foreign DNA or RNA.

关 键 词：CRISPR DNA LOADING 

分 类 号：Q55[生物学—生物化学]