大株红景天注射液治疗冠心病合并心力衰竭疗效及对患者血清HCY、Gal⁃3、NT⁃proBNP水平的影响  

Efficacy of Sofren injection in the treatment of coronary heart disease with heart failure and its effects on the serum levels of HCY,Gal⁃3 and NT⁃proBNP

作　　者：张志亮[1] 张鑫[1] 高卫芳[1] 袁宇[2] ZHANG Zhiliang;ZHANG Xin;GAO Weifang;YUAN Yu(Department of Pharmacy,The First Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan,China,453100;CCU,The First Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan,China,453100)

机构地区：[1]新乡医学院第一附属医院药剂科,河南新乡453100 [2]新乡医学院第一附属医院CCU,河南新乡453100

出　　处：《分子诊断与治疗杂志》2020年第5期611-615,共5页Journal of Molecular Diagnostics and Therapy

基　　金：2018年河南省医学科技攻关计划项目(2018020972)。

摘　　要：目的探讨大株红景天注射液治疗冠心病合并心力衰竭的临床疗效。方法将104例冠心病合并心力衰竭患者随机分为观察组和对照组各52例。对照组患者予以前列地尔治疗,观察组患者在此基础上予以大株红景天注射液治疗。比较两组患者临床疗效,观察治疗前后心功能[左室射血分数(LVEF)、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、心排血量(CO)]、心衰标志物[N⁃末端脑钠肽前体(NT⁃proBNP)]、内皮功能[内皮素(ET)、一氧化氮(NO)]、氧化应激[丙二醛(MDA)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)]以及血清同型半胱氨酸(HCY)、半乳凝集素⁃3(Gal⁃3)水平的变化情况。结果观察组患者治疗总有效率高于对照组(P<0.05);治疗20 d后,两组患者LVEF、CO均较治疗前升高,且观察组高于对照组,LVEDD、LVESD均较治疗前降低,且观察组低于对照组(P<0.05);治疗20 d后,两组患者血清NT⁃proBNP、ET、MDA、HCY、Gal⁃3水平均较治疗前降低,且观察组低于对照组(P<0.05),NO、SOD、CAT水平较治疗前升高,且观察组高于对照组(P<0.05)。结论大株红景天注射液治疗冠心病合并心力衰竭效果显著,可明显改善心功能和内皮功能,减轻心肌损伤,提高抗氧化应激能力,促进疾病转归。Objective To explore the clinical efficacy of Sofren injection in the treatment of coro⁃nary heart disease with heart failure.Methods 104 patients with coronary heart disease and heart failure were randomly divided into the observation group and the control group,with 52 cases in each group.Patients in the control group were treated with alprostadil while patients in the observation group were treated with So⁃fren injection plus alprostadil.The clinical efficacy of the two groups was compared,and the cardiac function[left ventricular ejection fraction(LVEF),left ventricular end⁃diastolic diameter(LVEDD),left ventricular end⁃systolic diameter(LVESD),cardiac output(CO)],heart failure marker[N⁃terminal pro⁃brain natriuretic peptide(NT⁃proBNP)],endothelial function[endothelin(ET),nitric oxide(NO)],oxidative stress[malo⁃naldehyde(MDA),superoxide dismutase(SOD),catalase(CAT)]and serum homocysteine(HCY)and ga⁃lectin⁃3(Gal⁃3)were observed before and after treatment.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After 20d of treatment,the LVEF and CO in the two groups were increased compared with those before treatment,and the two indexes in the ob⁃servation group were higher than those in the control group,and the LVEDD and LVESD were decreased com⁃pared with those before treatment,and the two indexes in the observation group were lower than those in the control group(P<0.05).After 20d of treatment,the serum levels of NT⁃proBNP,ET,MDA,HCY and Gal⁃3 in the two groups were decreased compared with those before treatment,and the levels in the observation group were lower than those in the control group(P<0.05),and the levels of NO,SOD and CAT were in⁃creased compared with those before treatment,and the levels in the observation group were higher than those in the control group(P<0.05).Conclusion Sofren injection has a significant effect on coronary heart disease with heart failure.It can significantly improve cardiac fun

关 键 词：冠心病 心力衰竭 大株红景天注射液 同型半胱氨酸 半乳凝集素⁃3 

分 类 号：R259[医药卫生—中西医结合]