Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3  

作　　者：QIU Pei CAI Run-Lin LI Lin SHE Zhi-Gang 

机构地区：[1]School of Chemistry,Sun Yat-Sen University,Guangzhou 510275,China [2] South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center,Guangzhou 510006,China

出　　处：《Chinese Journal of Natural Medicines》2020年第4期256-260,共5页中国天然药物（英文版）

基　　金：the National Natural Science Foundation of China (No. 21877133);Guangdong MEPP Fund (No. GDOE-2019A21);the Key Project of Natural Science Foundation of Guangdong Province (No. 2016A040403091) for generous support。

摘　　要：Three new isocoumarin derivatives,(S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one(1),(S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one(2) and(R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1 H-isochromen-3-yl) propyl acetate(3), along with four known compounds(4–7) were isolated from a mangrove endophytic fungus Penicillium sp. YYSJ-3. Their structures were established on the basis of the extensive spectroscopic data and HR-ESI-MS analysis. The absolute configurations of1–3 were further determined by X-ray diffraction analysis and optical rotations. Compounds 3, 6 and 7 showed promising inhibitory activity against α-glucosidase, which were stronger than that of the positive control 1-deoxynojirimycin(IC50 141.2 μmol·L-1).

关 键 词：Isocoumarin derivatives Penicillium sp. Structure elucidation α-Glucosidase inhibitory activity 

分 类 号：R284[医药卫生—中药学]