Using europium(Ⅲ) complex of 1,4,7,10-tetraazacyclododecane-1,4,7-triacedic acid Eu.DO3A as a luminescent sensor for bicarbonate  

作　　者：Lucile Bridou Lea Gundorff Nielsen Thomas Just Sorensen 

机构地区：[1]Nano-Science Center&Department of Chemistry,University of Copenhagen,Universitetsparken5,2100,Kebenhavn,Denmark [2]Ecole normale superieure de Lyon,15 parvis Rene Descartes,69342 Lyon,France

出　　处：《Journal of Rare Earths》2020年第5期498-505,共8页稀土学报（英文版）

基　　金：Project supported by the University of Copenhagen,the Novo Nordisk Foundation(grant number 4096);Carlsbergfondet,the Villum Foundation(grant number 14922);ENS Lyon。

摘　　要：Sensing of analyte s in biological fluids and biotechnological production media remains a challenge.He re,the luminescent response of the europium(Ⅲ)complex of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid(DO3A)to bicarbonate was investigated in detail.The response of Eu.DO3A to changes in bicarbonate concentration was studied in different buffers,and the influence of ionic strength,pH,and specific ions was determined.The response is found to depend on pH and ionic strength,but it is not possible to separate contributions from the sensing event from those in the bicarbonate activity.Prior to demonstrating the ability to determine the bicarbonate concentration in bioproduction media and serum,the influence of competing carboxy anions was evaluated.It is established that while competing anions bind stronger to the responsive complex,at the relevant concentration their contribution to the recorded signal is negligible.We are thus able to conclude that Eu.DO3A is a good platform for building a bicarbonate sensor.

关 键 词：Lanthanide luminescence Responsive lanthanide complexes Bicarbonate sensing Optical sensors Luminescent sensors Rare earths 

分 类 号：O641.4[理学—物理化学] TP212[理学—化学]