单克隆抗体及其抗感染作用的研究进展  

Advances in Monoclonal Antibody and Its Anti-Infection Effect

作　　者：崔乐乐 卜桐 刘兆基 张涵旭 史雨 井雯雯 李爱梅[1] 考文萍[1] 翟爱霞[1] CUI Le-le;BU Tong;LIU Zhao-ji;ZHANG Han-xu;SHI Yu;JING Wen-wen;LI Ai-mei;KAO Wen-ping;ZHAI Ai-xia(Teach.&Res.Div.of Microbiol.,Wu Lien-Teh Inst.,Key Lab.of Infect.&Immunol.of Heilongjiang Prov.,Pathobiol.Key Lab.of Heilongjiang Prov.,Sci.&Tech.Inno.Team for Infect.&Immunol.of Heilongjiang Prov.,Harbin 150081)

机构地区：[1]哈尔滨医科大学微生物学教研室,伍连徳研究所,黑龙江省感染与免疫重点实验室,黑龙江省普通高校病原生物学重点实验室,黑龙江省普通高校感染与免疫科技创新团队,黑龙江哈尔滨150081

出　　处：《微生物学杂志》2020年第2期87-92,共6页Journal of Microbiology

基　　金：黑龙江省教育厅科学技术研究项目(12541365);国家自然科学基金项目(81501737)。

摘　　要：骨髓瘤细胞和单个B细胞可融合形成杂交瘤细胞,这种细胞分离并克隆后可产生针对单一表位,且结构和功能相同的抗体,即单克隆抗体(monoclonal antibody,mAb)。单克隆抗体发展历程经历了四个阶段。其制备技术也在不断革新与发展。目前单克隆抗体技术发展日益成熟,在疾病治疗与诊断中发挥着关键的作用。单克隆抗体与天然抗体不同,具有效价高、特异性强、交叉反应少、可大量制备,靶向性高等特点。mAb可用于诊断及治疗感染性疾病、自身免疫病以及癌症等。对mAb的发展历程及mAb在抗感染性疾病中的应用进行简要阐述。Myeloma cells and single B cells can be fused to form hybridoma cells,after isolation and cloning can produce antibodies against a single epitope and have the same structure and function,namely monoclonal antibody(mAb).The development of monoclonal antibody has gone through four stages.Its preparation technology is also being steadily renovated and developed.At present,monoclonal antibody technology is becoming more and more mature,and plays a key role in the treatment and diagnosis of diseases.Monoclonal antibodies differ from natural antibodies in that they have high valence,strong specificity,little cross reaction,and can be prepared in great quantity,with high targeting,and other features.mAb can be used to diagnose and treat infectious diseases,autoimmune diseases and cancers etc.In this summary,the development course of mAb and its applications in anti-infectious diseases were briefly expatiated.

关 键 词：抗体 单克隆抗体 全人源单克隆抗体 抗感染 感染性疾病 

分 类 号：Q939.93[生物学—微生物学]