Iron-Catalyzed Aminomethyloxygenative Cyclization of Hydroxy-α-diazoesters with N,O-Aminals  

作　　者：Suchen Zou Tianze Zhang Siyuan Wang Hanmin Huang 

机构地区：[1]Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry,Center for Excellence in Molecular Synthesis,University of Science and Technology of China,Chinese Academy of Sciences,Hefei,Anhui 230026,China [2]State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gonsu 730000,China

出　　处：《Chinese Journal of Chemistry》2020年第4期389-393,共5页中国化学（英文版）

基　　金：This research was supported by the National Natural Science Foundation of China(Nos.21925111,21672199,21790333,and 21702197);the Fundamental Resedrch Funds for the Central Universities(No.WK2060190086).

摘　　要：Summary of main observation and conclusion A new and eficient cyclization reaction has bleen developed to synthesize cyclic a,a-disubstituted B-amino esters via iron-catalyzed intramolecular aminomethyloxygenative cyclization of diazo compounds with N,O-aminal under mild reaction condi-tions.A broad range of hydroxy-a diazoesters with different substituents and various N,O-aminals were compatible with this protocol,affording the corresponding a,a-disubstitutedβ-amino esters bearing a five-to eight-membered oxacycle in good yields.

关 键 词：ESTERS SUBSTITUTED CYCLIZATION 

分 类 号：O62[理学—有机化学]