Click Chemistry:Evolving on the Fringe  

作　　者：Long Xu Jiajia Dong 

机构地区：[1]Key Laboratory of Organofluorine Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,345 Ling-Ling Road,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2020年第4期414-419,共6页中国化学（英文版）

基　　金：We acknowledge the National Natural Science Foundation of China(NSFC 21672240,NSFC 25721421002);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB200203);the Key 258 Research Program of Frontier Sciences(CAS,Grant No.QYZDB-SSWSLH-028);Shanghai Sciences and 259 Technology Committee(18JC1415500,18401933502)for their financial support.

摘　　要：Summary The article herein briefly introduces the story of the birth of click chemistry and its evolution after that.A new angle to interpret click reac-tions was proposed using the"reactivity availability-functionality"trilogy.CuAAC(Copper-catalyzed azide-alkyne cycloaddition),the most popular click reaction by far,was revisited along with the thiol-ene,metal-free AAC,SuFEx(sulfur(VI)fluoride exchange)and the lately discovered diazotransfer pro-cess.By encountering more and more near-perfect reactions,click chemistry is evolving and expanding on the fringe of the chemistry and dfferent scien-tific disciplines,destination unknown.

关 键 词：FLUORIDE AZIDE herein 

分 类 号：O6[理学—化学]