液相色谱质谱法检测尿液中的痕量甲基苯丙胺  

Test Trace Methamphetamine in Urine by UPLC-MS/MS

作　　者：吴辉 Wu Hui

机构地区：[1]福建历思司法鉴定所,福建厦门361000

出　　处：《化工设计通讯》2020年第6期157-158,共2页Chemical Engineering Design Communications

摘　　要：目的对吸毒人员的尿液追溯更早时间吸毒的证据,为公安机关办案提供更加高效、科学的证据。方法使用固相萃取(阳离子交换柱),对尿液中甲基苯丙胺进行提取浓缩后,使用超高灵敏度的液相色谱串联质谱仪进行检测。结果甲基苯丙胺浓度在5~1000pg/mL时,线性良好。结论该方法使用固相萃取,满足高灵敏液质的上机要求,通过实际案例证实能追溯到更久之前的吸毒证据。Objective Trace through the earlier urine of drug users,which provides more efficient and scientific evidence for public security organs to handle cases.Results When the concentration range of methamphetamine is from 5pg/mL to 1000pg/mL,the linearity is good.Conclusion The SPE can satisfy the requirement of UPLC-MS/MS,proof the drug use can be traced back to a long time ago through actual cases.

关 键 词：痕量甲基苯丙胺 液相色谱串联质谱 固相萃取 

分 类 号：R285.5[医药卫生—中药学]