激素性股骨头坏死动物模型国内外研究现状及进展  

Domestic and foreign research situation and advances of animal models of steroid-induced osteonecrosis of the femoral head

作　　者：岳聚安 郭晓忠 王冉东[1] 李兵 孙强[1] 刘忘言 陈蛟 李迎楠 Yue Ju’an;Guo Xiaozhong;Wang Randong;Li Bing;Sun Qiang;Liu Wangyan;Chen Jiao;Li Yingnan(Department of Orthopedic Surgery, Aviation General Hospital of China Medical University, Beijing 100012, China)

机构地区：[1]中国医科大学航空总医院关节外科,北京100012

出　　处：《中华损伤与修复杂志（电子版）》2020年第2期142-145,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：航空总医院院级课题(YJ202018)。

摘　　要：长期服用激素所引发的股骨头缺血性坏死越来越受到大家的关注。成功建立激素性股骨头坏死(SONFH)动物模型,有助于从根源上认识激素相关的股骨头缺血性坏死的发病机制,为预防股骨头坏死(ONFH)的发生及塌陷奠定良好基础。虽然有很多学者选择不同的动物,采用不同的方法,致力于寻找与人ONFH病理变化相似的动物模型,但目前的现况不能令大家十分满意。本文总结了SONFH动物模型病理、影像学诊断及模型动物的选择、制备方法的研究现状及进展,为SONFH的研究提供参考。Avascular necrosis of femoral head caused by long-term use of hormones has attracted more and more attention.The successful establishment of animal model of steroid-induced osteonecrosis of the femoral head(SONFH)may help us to understand the pathogenesis of SONFH,and lays a good foundation for preventing the occurrence and collapse of osteonecrosis of the femoral head(ONFH).Although many scholars choose different animals and methods to establish animal models of ONFH to find similar pathological changes to human,the current situation is not satisfactory.In this paper,the research status and progress of pathological and imaging diagnosis,selection of animals,preparation methods of SONFH in animals were summarized to provide some reference for the research of SONFH.

关 键 词：股骨头坏死 激素类 模型 动物 

分 类 号：R68[医药卫生—骨科学]