Kallistatin生物学作用的研究进展  

Advances in the Biological Effects of Kallistatin

作　　者：黄玉香 米雪[2] 刁勇 HUANG Yu-xiang;MI Xue;DIAO Yong(Department of Pharmacy,Quanzhou Medical College,Quanzhou 362011,China;School of Medicine,Huaqiao University,Quanzhou 362021,China)

机构地区：[1]泉州医学高等专科学校药学院,福建泉州362011 [2]华侨大学医学院,福建泉州362021

出　　处：《海峡药学》2020年第4期5-8,共4页Strait Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81502687,81371669);福建省高校产学合作重大项目(2018Y4009);福建省中青年教师教育科研项目(JA14392);泉州医学高等专科学校重点科研项目(XJK1601A);华侨大学科研基金资助项目(605-50Y17076)。

摘　　要：组织激肽释放酶结合蛋白(Kallistatin,KAL)是一种丝氨酸蛋白酶抑制剂,广泛分布于多种器官及体液中,具有抗炎、抗氧化应激、抗血管生成及抗肿瘤等生物学作用,其作用机制与TNF-α、VEGF等密切相关,通过多条信号通路实现。KAL在临床疾病及药物开发中均有重要价值,本文就KAL的主要生物学作用及其作用机制的最新研究进展进行阐述。Kallistatin(KAL) is a unique serine proteinase inhibitor isolated from normal human serum as a kallikrein-binding protein.KAL is widely distributed in multiple organs and body fluids.It has biological effects such as anti-inflammatory,anti-oxidative stress,anti-angiogenesis and anti-tumor,and its mechanisms are closely related to TNF-α,VEGF and so on,which functions through multiple signaling pathways.KAL plays an important role in clinical diseases and drug development.This paper elaborates the main biological effects of KAL and its mechanisms.

关 键 词：组织激肽释放酶结合蛋白 抗炎 抗肿瘤 

分 类 号：R965[医药卫生—药理学]