六棱菊对阿霉素致小鼠肾损伤保护作用的实验研究  

Experimental Study of Laggera Alata on Adriamycin-induced Nephritis in Mice

作　　者：池志珍[1] 郑时桢 郭晓芳[1] 吴学辉[1] CHI Zhi-zhen;ZHENG Shi-zhen;GUO Xiao-fang;WU Xue-hui(People′s Hospital of Fujian University of Chinese Medicine,Fuzhou 350001,China)

机构地区：[1]福建中医药大学附属人民医院,福建福州350000

出　　处：《海峡药学》2020年第4期37-39,共3页Strait Pharmaceutical Journal

基　　金：福建省科技厅计划项目课题(福建省肾系疾病中草药的调查与筛选)(编号:2016Y0049)。

摘　　要：目的探讨六棱菊对阿霉素致小鼠肾损伤的保护作用。方法建立阿霉素诱导小鼠的肾病模型,连续灌服六棱菊水煎液4周后,检测小鼠血清中的尿素氮(BUN)和肌酐(Cr)含量;计算肾脏指数;ELISA法检测肾组织中白介素-8(IL-8)的含量。结果六棱菊治疗后小鼠血清中的BUN和Cr的含量、肾脏指数及肾组织中IL-8蛋白表达量均较模型组小鼠明显减少(P<0.05)。结论六棱菊对阿霉素所致小鼠肾损伤具有一定的保护作用。OBJECTIVE To explore the protective effect of Laggera alata on adriamycin-induced kidney injury in mice.METHODS A model of adriamycin-induced nephropathy in mice was established,and the blood content of urea nitrogen(BUN) and creatinine(Cr) in the serum of mice was measured after continuous decoction of Laggera alata for 4 weeks.The kidney index was calculated;Interleukin-8(IL-8) content in tissues is detected by ELISA.RESULTS The levels of BUN and Cr in serum,kidney index and expression of IL-8 protein in kidney tissues were significantly reduced in the mice after treatment with Laggera alata(P<0.05).CONCLUSION Laggera alata has certain protective effects on kidney injury induced by adriamycin in mice.

关 键 词：六棱菊 阿霉素 肾损伤 

分 类 号：R965[医药卫生—药理学]