乙型肝炎病毒相关检测方法的对比分析及其展望  

Comparative analysis and prospect of hepatitis B virus detection methods

作　　者：马丽娜 张俊涛 李胜男 Ma Lina;Zhang Juntao;Li Shengnan(Heilongjiang Kingmed Center for Clinical Laboratory,Laboratory Diagnosis Department,Haerbin 150000,China)

机构地区：[1]黑龙江金域医学检验所有限公司实验诊断部,哈尔滨150000

出　　处：《中华临床实验室管理电子杂志》2020年第1期2-5,共4页Chinese Journal of Clinical Laboratory Management(Electronic Edition）

摘　　要：乙型肝炎对人体危害极大且易传染,全球每年约有100万人死于乙型肝炎病毒感染。该病毒很难彻底清除,乙型肝炎也极难彻底治愈,所以做好对乙肝的早发现、早治疗以及在治疗过程中病情的检测就显得尤为重要。本文首先介绍了目前临床上常用的检测方法胶体金法、酶联免疫吸附法、时间分辨荧光分析法、化学发光免疫法以及FQ-PCR法,并对它们进行了详细的对比分析;然后又对乙型肝炎病毒检测的研究新方向进行了详细介绍;最后结合乙型肝炎检测的现状和发展方向进行了讨论和展望。Hepatitis B virus(HBV)is extremely harmful and highly contagious.About one million people worldwide has been died of HBV infection every year.The virus is hard to be completely eradicated,and full remission is impossible.It is particularly important to do a good job in the early detection,early treatment of the disease and detection of HBV in the treatment process.This paper first introduces the common clinical detection methods such as colloidal gold method,enzyme-linked immunosorbent assay,time-resolved fluorescence assay,chemiluminescent immunoassay and FQ-PCR method,and makes a detailed comparative analysis of them.Then it introduces the new research direction of HBV detection.Finally,the current situation and development direction of HBV detection are discussed and prospected.

关 键 词：乙型肝炎病毒 化学发光免疫法 时间分辨荧光分析法 酶联免疫法 

分 类 号：R446.6[医药卫生—诊断学] R512.62[医药卫生—临床医学]