妊娠期肝病的临床特征及研究进展  

Research advances in the clinical features of liver disease during pregnancy

作　　者：段兴平 王燕[2] 黄常友 郑会贤[3] 罗一[3] 覃正文 任郁[3] DUAN Xingping;WANG Yan;HUANG Changyou;ZHENG Huixian;LUO Yi;QIN Zhengwen;REN Yu(Department of Pharmacy,Maternal and Child Health Hospital of Zigong,Zigong,Sichuan 643000,China;Department of Neonatology,Maternal and Child Health Hospital of Zigong,Zigong,Sichuan 643000,China;Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Zigong, Zigong, Sichuan 643000, China)

机构地区：[1]自贡市妇幼保健院药剂科,四川自贡643000 [2]自贡市妇幼保健院新生儿科,四川自贡643000 [3]自贡市妇幼保健院妇产科,四川自贡643000

出　　处：《临床肝胆病杂志》2020年第6期1407-1411,共5页Journal of Clinical Hepatology

基　　金：自贡市科技局重点科技计划项目(2018SHFZ08);自贡市哲学社会科学重点研究项目(YDJKY19-09)。

摘　　要：严重的妊娠期肝病临床罕见。妊娠期肝病最常见的发病原因为肝功能紊乱,总发病率约为3%。妊娠期肝病主要分为妊娠期特有肝病和非妊娠期特有肝病,即妊娠前已经存在的基础性肝病或妊娠期间偶发肝病。对妊娠期已存在的肝脏疾病及合并的肝脏疾病进行鉴别诊断,有助于改善母婴结局。在临床诊断、选择治疗、干预方式时,应优先考虑对母婴的潜在影响。介绍了妊娠期主要肝脏疾病的概况、发病机制、治疗和妊娠结局的最新研究进展,阐述了患基础性肝病的妊娠风险及应对措施,以指导临床诊疗和患者管理。Severe liver disease during pregnancy is uncommon in clinical practice.The most common cause of liver disease during pregnancy is liver dysfunction,with an overall prevalence rate of approximately 3%.Liver disease during pregnancy is classified into the liver diseases directly caused by pregnancy and those co-existing with pregnancy,i.e.,pre-existing liver disease or occasional liver disease during pregnancy.A differential diagnosis of pre-existing and co-existing liver diseases may help to improve maternal and fetal outcome.During clinical diagnosis and selection of treatment and intervention measures,priority should be given to the potential impact on mother and fetus.This article introduces the latest research advances in the general information,pathogenesis,treatment,and pregnancy outcome of major liver diseases during pregnancy and elaborates on the risk of pregnancy and related coping measures for patients with pre-existing liver disease,so as to guide clinical diagnosis and treatment and patient management.

关 键 词：妊娠并发症 肝疾病 诊断 治疗学 

分 类 号：R714.25[医药卫生—妇产科学] R575[医药卫生—临床医学]