欣普贝生和宫颈扩张球囊在妊娠晚期中引产效果比较的Meta分析  

Comparison of labor induction effects of dinoprostone and transcervical double-balloon catheter in late pregnancy:a Meta-analysis

作　　者：杨蓓 王霜[2] 温琴琴 林进强 王祥珍[1] Yang Bei;Wang Shuang;Wen Qinqin;Lin Jinqiang;Wang Xiangzhen(Department of Gynaecology,Nanshan Maternity&Child Healthcare Hospital of Shenzhen,Shenzhen,Guangdong,518000,China;Department of Sports Medicine,Peking University Shenzhen Hospital,Shenzhen,Guangdong,518000,China)

机构地区：[1]深圳市南山区妇幼保健院妇科,广东深圳518000 [2]北京大学深圳医院运动医学科,广东深圳518000

出　　处：《当代医学》2020年第17期1-6,共6页Contemporary Medicine

基　　金：广东省医学科学技术研究基金项目(A2017202);广东省自然科学基金项目(2017A030310616)。

摘　　要：目的运用Meta分析对欣普贝生和宫颈扩张球囊在妊娠晚期中的引产效果进行比较,为临床治疗方案的选择提供参考依据。方法运用计算机检索ELSEVIER ScienceDirect(SDOS)数据库、PubMed Central-NLM期刊全文库、SpringerLink数据库、Wiley Online Library、中国生物医学文献数据库、维普信息资源系统、中国数字图书馆、万方数据库等中外电子数据库,并且辅佐文献追溯、手工检索等方法,检索时间从1990年1月至2017年7月,收集关于欣普贝生和宫颈扩张球囊在妊娠晚期中的引产疗效对比的临床试验,按照纳入及排除标准筛选出符合要求的文献并进行质量评价,而后运用RevMan 5.3软件整合各个研究的临床观察指标进行统计学分析。结果最终共13篇文献纳入研究,包括8篇中文文献和5篇英文文献,欣普贝生组患者916例,球囊组患者932例。Meta分析显示,在干预后Bishop评分、引产至分娩时间、总产程、阴道分娩率、羊水粪染发生率、新生儿窒息发生率方面,两组间比较差异无统计学意义。在胎心异常发生率方面,两组间比较差异有统计学意义,球囊组的发生率低于欣普贝生组(P<0.05)。结论与欣普贝生在妊娠晚期中引产的效果相比,宫颈扩张球囊引起的胎心异常发生率更低,两者其余的临床效果相似。Objective Perform a meta-analysis to evaluate the labor induction effects between dinoprostone and transcervical double-balloon catheter.Methods Eligible studies were identified from the electronic databases including ELSEVIER,Science Direct,PubMeb Central-NLM,SpringerLink,Wiley Online Library,CNKI,WanFang Data and VIP,etc.In addition,it also assists in literature tracing,manual retrieval and other methods.The searching period was limited from January 1990 to July 2017.After then these studies were furtherly screend in accordance with the inclusion and exclusion criteria.A meta-analysis was performed by the software RevMan 5.3 to analyse the outcome measures.Results A total of 13 articles were included in the study,including 8 Chinese articles and 5 English articles.916 cases were in the Simpson group and 932 in the balloon group.Meta analysis showed that there was no significant difference between the two groups in Bishop score,induction to delivery time,total labor process,vaginal delivery rate,incidence of amniotic fluid fecal staining,incidence of neonatal asphyxia.In terms of the incidence of abnormal fetal heart rate,the difference between the two groups was statistically significant,and the incidence of balloon group was lower than that of Simpson group(P<0.05).Conclusion The incidence of fetal heart rate abnormality caused by cervical dilatation balloon was lower than that induced by Simpson in the third trimester,and the other clinical effects were similar.

关 键 词：欣普贝生 宫颈扩张球囊 引产 META分析 

分 类 号：R719.3[医药卫生—妇产科学]