南京市79例普通型新型冠状病毒肺炎患者的用药情况分析及用药合理性评价  

Drug utilization patterns and rationality of prescriptions for 79 patients with moderate COVID-19 in Nanjing

作　　者：李菁[1] 朱凌云 LI Jing;ZHU Lingyun(Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210003,China)

机构地区：[1]南京中医药大学附属南京医院(南京市第二医院)

出　　处：《山东医药》2020年第15期22-26,共5页Shandong Medical Journal

摘　　要：目的分析南京中医药大学附属南京医院79例普通型新型冠状病毒肺炎(COVID-19)患者临床用药情况,评价其用药合理性。方法通过查阅电子病历收集79例普通型COVID-19患者药物应用种类、药物应用例次、药物应用天数、用药规格等,并采用合理用药指标限定日剂量(DDD)、用药频度(DDDs)、限定日费用(DDC)和药物利用指数(DUI)评价用药合理性。结果79例普通型COVID-19患者共应用25大类、572种药物。25类药物中,用药例次数最多的是抗病毒化学药。用药时间和DDDs排序第一的是止咳化痰药。主要常用的药品中,用药例次数和用药时间排序第一的是重组人干扰素α1b注射液。DDDs排序前20的药品中,乙酰半胱氨酸片排第一位。用药总金额和DDC最高的是静注人免疫球蛋白。注射用胸腺法新(日达仙)和盐酸氨溴索注射液的DUI大于2,提示用量较大。结论本院以重组人干扰素α1b注射液以及乙酰半胱氨酸片等7种药品构成基本用药,剂量、方法大多与《新型冠状病毒肺炎诊疗方案》推荐相符合。大部分药品应用合理,但存在抗病毒制剂、干扰素和止咳化痰药用量较大的情况;同时,普通型COVID-19患者存在超说明书使用激素类药物的情况。Objective To analyze drug utilization patterns and rationality of prescriptions in patients with coronavirus disease 2019(COVID-19).Methods Drug application types,drug application cases,drug application days and drug specifications of 79 moderate inpatients were collected through electronic medical record from the hospital information system(HIS system).Defined daily dose(DDD),defined daily dose system(DDDs),defined daily cost(DDC)and drug utilization index(DUI)were used to assess rationality of drug use.Results A total of 572 drugs in 25 categories were prescribed to 79 moderate patients with COVID-19.Among the 25 types of drugs,the most frequently used were antiviral agents;cough and phlegm medicine ranked first in the number of medication days and DDDs;recombinant human interferon-α1b injection was the first of the most commonly used medicines in terms of number of medication cases and days of medication.According to the first 20th medications based on DDDs order,DDDs of acetylcysteine tablets was the highest.The total cost and DDC of immunoglobulin were the highest.The DUI of thymfaxine(Ridaxian)and ambroxol hydrochloride injection was much higher than 2,suggesting a large dosage.Conclusions Seven kinds of medications for main clinical treatment were prescribed in our hospital such as recombinant human interferon-α1b injection and acetylcysteine tablets.The dosage and method were mostly in accordance with the recommendation of Diagnosis and Treatment Protocol for COVID-19.The prescriptions were largely evidence-based,but the dosages of antiviral agents,cough remedy and interferon were at a high level,on the other hand,there were moderate COVID-19 patients whose steroid drugs were prescribed beyond the guideline.

关 键 词：新型冠状病毒肺炎 治疗药物 重组人干扰素Α1B 乙酰半胱氨酸 用药合理性 

分 类 号：R459.1[医药卫生—治疗学]