利伐沙班对下肢静脉血栓栓塞症患者血流动力学及血管内皮功能的影响  

Effect of rivaroxaban on hemodynamics and vascular endothelial function in patients with lower limb vein thrombosis embolism

作　　者：孙虎 刘金昊 徐益鸣[1] 杨东海[1] 黄小进[1] Sun Hu;Liu Jinhao;Xu Yiming;Yang Donghai;Huang Xiaojin(Department of Vascular Surgery,Zhongshan Hospital,Xiamen University,361004,China)

机构地区：[1]厦门大学附属中山医院血管外科,厦门361004

出　　处：《国际医药卫生导报》2020年第12期1748-1751,共4页International Medicine and Health Guidance News

摘　　要：目的探讨利伐沙班对下肢静脉血栓栓塞症患者血流动力学及血管内皮功能的影响。方法选择2018年4月至2019年4月本院收治的下肢静脉血栓栓塞症患者100例,按照随机数字表法将其分为对照组和观察组,各50例。对照组男32例,女18例;年龄范围35~69岁,年龄(52.15±15.43)岁;病程范围1~90 d,病程(12.13±5.27)d;其中左下肢28例,右下肢17例,双下肢5例。观察组男30例,女20例;年龄范围35~69岁,年龄(51.84±15.26)岁;病程范围1~90 d,病程(12.12±5.37)d;其中左下肢27例,右下肢18例,双下肢5例。对照组采用传统抗凝药治疗,观察组采用利伐沙班治疗。对比两组疗效、血流动力学及血管内皮功能。结果观察组治疗总有效率为94.00%(47/50),高于对照组的80.00%(40/50),差异具有统计学意义(P<0.05);观察组治疗后sICAM-1、TXB2以及ET-1水平较对照组低,6-keto-PGF1α及NO高于对照组,差异具有统计学意义(均P<0.05);观察组治疗后FIB、HSV、LSV均较对照组低,差异具有统计学意义(均P<0.05)。结论利伐沙班对下肢静脉血栓栓塞症患者的治疗效果较佳,能够改善患者血流动力学及血管内皮功能。Objective To investigate the effect of rivaroxaban on hemodynamics and vascular endothelial function in patients with lower limb vein thrombosis embolism.Methods 100 patients with lower limb vein thrombosis embolism who were admitted into our hospital from April,2018 to April,2019 were divided into a control group and an observation group according to the random number table,with 50 cases in each group.There were 32 males and 18 females in the control group;they were 35-69 years old,and the mean age was(52.15±15.43);the disease course was 1-90 days,and the mean disease course was(12.13±5.27)days;there were 28 cases of left lower limb,17 cases of right lower limb,and 5 cases of both lower limbs.There were 30 males and 20 females in the observation group;they were 35-69 years old,and the mean age was(51.84±15.26);the disease course was 1-90 days,and the mean disease course was(12.12±5.37)days;there were 27 cases of left lower limb,18 cases of right lower limb,and 5 cases of both lower limbs.The control group was treated with traditional anticoagulant drugs,and the observation group with rivaroxaban.The efficacies,hemodynamics,and vascular endothelial function were compared between the two groups.Results The total effective rate of the observation group[94.00%(47/50)]was higher than that of the control group[80.00%(40/50)],with a statistical difference(P<0.05).After the treatment,the levels of sICAM-1,TXB2,and ET-1 were lower and the levels of 6-keto-PGF1αand NO were higher in the observation group than in the control group(all P<0.05).After the treatment,the FIB,HSV,and LSV in the observation group were lower than those in the control group(all P<0.05).Conclusion Rivaroxaban in the treatment of patients with lower limb vein thrombosis embolism has better curative effect,and can improve their hemodynamics and vascular endothelial function.

关 键 词：下肢静脉血栓 利伐沙班 栓塞症 血流动力学 血管内皮功能 

分 类 号：R543.6[医药卫生—心血管疾病]