普通型新型冠状病毒肺炎患者炎症反应及凝血功能变化  

Changes in inflammatory response and blood coagulation function of COVID-19 with common type

作　　者：宋伟南[1] 石亚玲[1] 陈星[1] 李凌华[2] 刘丽儿[1] 邝美华 Song Weinan;Shi Yaling;Chen Xing;Li Linghua;Liu Li’er;Kuang Meihua(Department of Clinical Laboratory,Guangzhou Eighth People's Hospital,Guangzhou 510060,China;Infectious Disease Center,Guangzhou Eighth People's Hospital,Guangzhou 510060,China)

机构地区：[1]广州市第八人民医院检验科,510060 [2]广州市第八人民医院感染病中心,510060

出　　处：《国际医药卫生导报》2020年第11期1482-1485,共4页International Medicine and Health Guidance News

基　　金：广州市高水平临床重点专科传染病专科(2019-2021)。

摘　　要：目的探讨普通型新型冠状病毒肺炎(COVID-19)患者机体炎症反应及凝血功能的变化情况,为临床诊疗提供参考依据。方法选取2020年1至2月期间本院收治的54例普通型COVID-19患者作为研究对象,并选择2019年11月的健康体检者作为对照组。收集患者治疗前后和对照组有关炎症反应及凝血功能指标进行统计分析,包括:C反应蛋白(CRP)、白细胞(WBC)、中性粒细胞计数(NEU#)、淋巴细胞计数(LYM#)、单核细胞计数(MON#)、血小板(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆凝血酶时间(TT)、血浆纤维蛋白原(Fib)、血浆纤维蛋白原降解产物(FDP)、D-二聚体。结果普通型COVID-19患者治疗前CRP水平显著高于治疗后及对照组;WBC与PLT在各组间差异均有统计学意义;NEU#、LYM#、FIB、FDP和D-二聚体治疗前后差异均无统计学意义,而与对照组比较差异有统计学意义。结论普通型COVID-19患者CRP水平变化与病情进程相关;WBC与PLT可辅助诊断COVID-19;D-二聚体在治疗前与治疗后的中位数均高于参考范围,是否具有诊疗意义,需进一步探讨。Objective To analyze the changes in inflammatory response and blood coagulation function of COVID-19 with common type and provide a reference for clinical diagnosis and treatment.Methods 54 patients with COVID-19 with common type admitted to our hospital from January to February 2020 were selected as the study objectives,and healthy physical examinees in November 2019 were selected as the control group.We retrospectively analyzed and compared the indexes including C-reactive protein(CRP),white blood cells(WBC),neutrophil count(NEU#),lymphocyte count(LYM#),mononuclear cell count(MON#),platelet(PLT),prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fib),fibrinogen degradation products(FDP),D-dimer before and after treatment,and analyze their clinical significance.Results The CRP level of the COVID-19 group before treatment was significantly higher than that after treatment and that of the control group.There were statistically significant differences in WBC and PLT between the two groups.There were no statistically significant differences in NEU#,LYM#,FIB,FDP,and D-dimer before and after treatment in the COVID-19 group,but there were statistically significant differences between the COVID-19 group and the control group.Conclusions Change in CRP level is associated with disease progression.WBC and PLT can assist the diagnosis of COVID-19.The median values of D-dimer before and after treatment are above the reference range,and whether it has clinical significance needs to be further discussed.

关 键 词：新型冠状病毒肺炎(COVID-19) C反应蛋白 白细胞 血小板 D-二聚体 

分 类 号：R563.1[医药卫生—呼吸系统]