GnRha降调和非降调下HRT-FET中内源性LH水平与妊娠结局的关系分析  

Analysis of the relationship between the level of endogenous LH and pregnancy outcomes in the cycle of hormone replace treatment and frozen-thawed embryo transfer(HRT-FET)in infertile women with or without GnRha

作　　者：罗燕群[1] 易艳红[1] 黄莉[1] 朱秀兰[1] 董梅[1] 张曦倩[1] 刘风华[1] Luo Yanqun;Yi Yanhong;Huang Li;Zhu Xiulan;Dong Mei;Zhang Xiqian;Liu Fenghua(Center for Reproductive Medicine,Guangdong Women&Children Hospital,Guangzhou 511400,China)

机构地区：[1]广东省妇幼保健院生殖医学中心,广州511400

出　　处：《国际医药卫生导报》2020年第11期1494-1498,共5页International Medicine and Health Guidance News

基　　金：广东省医学科学技术研究基金(B2019019)。

摘　　要：目的探讨GnRha降调和非降调下激素替代-冻融胚胎移植周期中不同内源性促黄体生成素(LH)增高水平对妊娠结局的影响。方法回顾性分析2015年1月至2018年10月在本院行GnRha降调和非降调下激素替代-冻融胚胎移植(HRT-FET)且年龄≤35周岁以及基础LH水平<10 IU/L的非子宫内膜异位症患者2313个周期的临床资料。根据有无GnRha降调分为降调下HRT-FET组(225个)和无降调HRT-FET组(2088个),再将无降调HRT-FET患者根据冻融胚胎移植中最高一次的LH水平分为3组:A组(LH<10 IU/L)、B组(LH 10~19.99 IU/L)和C组(LH≥20 IU/L)。比较无降调HRT-FET患者不同LH水平组间妊娠结局的差异和进一步比较无降调LH升高患者(≥20 IU/L)和降调下LH降低(LH<10 IU/L)患者妊娠率等结局的差异。结果A、B、C 3组患者的取卵年龄、移植胚胎数、妊娠率和种植率均无统计学差异(均P>0.05),GnRha降调组较非降调组患者的妊娠率和种植率明显降低(均P<0.05)。结论非子宫内膜异位症患者HRT-FET中出现LH增高对妊娠结局可能无不良影响,GnRha降调并不改善妊娠率。Objective To investigate the effect of different elevated luteinizing hormone(LH)levels on pregnancy outcomes of women in the cycle of hormone replace treatment and frozen-thawed embryo transfer(HRT-FET)with or without GnRha.Methods The clinical data of 2313 cycles of non-endometriosis women with the age≤35 years old and basic LH<10 IU/L who underwent HRT-FET with or without GnRha in our hospital from January 2015 to October 2018 was retrospectively analyzed.According the usage of GnRha or not,they were divided into GnRha HRT-FET group(225 cycles)and HRT-FET group(2088 cycles).According to the highest level of endogenous LH in HRT-FET group,the cycles were divided into three groups:group A(<10 IU/L),group B(10-19.99 IU/L),and group C(≥20 IU/L).The pregnancy outcomes among different groups were compared.Results There were no statistically significant differences in age of egg retrieval,number of embryo transfer,clinical pregnancy rate,and planting rate among group A,B,C(all P>0.05).The clinical pregnancy rate and planting rate in GnRha HRT-FET group were significantly lower than those in HRT-FET group(all P<0.05).Conclusions Maybe there were no adverse effects of increased level of endogenous LH on pregnancy outcomes in HRT-FET cycles for non-endometriosis patients.The usage of GnRha does not increase the pregnancy rate.

关 键 词：促黄体生成素 激素替代-冻融胚胎移植 妊娠结局 GnRha降调 

分 类 号：R714.8[医药卫生—妇产科学]