三维适形放疗联合高-低氧治疗老年食管癌的临床疗效观察  

Clinical Efficacy Observation of 3D Conformal Radiotherapy Combined with Oxygen Therapy in the Treatment of Elderly Esophageal Cancer

作　　者：姜孝娟[1] 黄勇[1] 毕金玲 Jiang Xiaojuan;Huang Yong;Bi Jinling(Department of Radiotherapy,Hefei No.2 Peoples’Hospital,Hefei,Anhui,230011)

机构地区：[1]安徽省合肥市第二人民医院肿瘤科,合肥230011

出　　处：《辐射防护通讯》2019年第6期10-13,共4页Radiation Protection Bulletin

摘　　要：本文探讨吸氧疗法对老年食管癌三维适形放疗增敏作用。收集我院72例病理学诊断明确为食管鳞癌患者,随机分成2组,治疗组为放疗联合高低氧疗36例,对照组为单纯放疗36例;放疗方式均为三维适形放疗(3DCRT),放疗剂量为57.6~64 Gy(1.8~2.0 Gy/32次);治疗组患者在每日开始行三维适形放疗前予以5 L/min流量吸氧2小时,随后给予放疗,放疗结束后持续予以3 L/min低流量氧疗至下次放疗前2小时;对照组只行单纯性放射治疗。结果表明,治疗组与对照组在放射性肺炎发生率及放射性食管炎发生率上均差异明显(p<0.05),近期缓解率治疗组和对照组分别为85.3%和57.6%,两组差异明显(p<0.05);1年生存率方面,两组未见明显差异。以上结果说明三维适形放疗联合高低氧治疗能提高近期有效率,同时在放射治疗不良反应方面能减轻放射性肺炎及放射性食管炎发生,临床可以考虑推广应用。The sensitization effect of oxygen therapy on 3D conformal radiotherapy for elderly esophageal cancer is discussed.A total of 72 patients with esophageal squamous cell carcinoma diagnosed by pathology in our hospital were randomly divided into 2 groups of equal numbers.Patients in the treatment group were given oxygen at 5 L/min for 2 hours before the beginning of radiotherapy,then at 3 L/min until 2 hours before the next radiotherapy.The control group received only radiotherapy.The radiotherapy method was 3D conformal radiotherapy(3DCRT),with a dose of 57.6-64 Gy(1.8-2.0 Gy/32f).The results showed that there were significant differences in the incidence of radiation pneumonia and radiation esophagitis between the 2 groups,with short-term remission rates of 85.3%and 57.6%respectively.There was no significant difference in 1-year survival between groups.It indicates that,combined with oxygen therapy,3DCRT can improve the short-term efficacy and also reduce the occurrence of radiation pneumonia and radiation esophagitis in terms of adverse reactions of radiotherapy,which can be considered for clinical application.

关 键 词：食管癌 高低氧 三维适形放疗 

分 类 号：R815[医药卫生—放射医学]