8组家族聚集性发病的新型冠状病毒肺炎胸部CT表现及转归  

CT findings and outcome with family clustering coronavirus disease 2019 in 8 families

作　　者：江芮 刘晋新[1] 张烈光[1] 黄德扬[1] 陈碧华 瞿静 林琳[1] 余成成 凌洲焜 Jiang Rui;Liu Jinxin;Zhang Lieguang;Huang Deyang;Chen Bihua;Qu Jing;Lin Lin;Yu Chengcheng;Ling Zhoukun(Department of Radiology,Guangzhou Eighth Peoplep's Hospital,Guangzhou Medical University,Guangzhou 510060,China)

机构地区：[1]广州医科大学附属广州市第八人民医院放射科,广州510060

出　　处：《新发传染病电子杂志》2020年第2期87-90,共4页Electronic Journal of Emerging Infectious Diseases

摘　　要：目的探讨8组家庭共25例聚集性发病新型冠状病毒肺炎的胸部CT表现及转归。方法回顾性分析在广州市第八人民医院收治的8组家族聚集性新型冠状病毒肺炎患者临床及CT影像学资料。结果7例(28.0%)从发病到治愈出院胸部CT始终呈阴性,另有4例(16.0%)入院6d后胸部CT呈阳性,2例(8.0%)为单肺叶散在病灶,16例(64.0%)为双肺多发病灶,主要表现为磨玻璃影(16/25,64.0%);而少数出现纤维条索影与磨玻璃影共存(2/25,8.0%),部分伴双侧胸膜增厚(3/25,12.0%)。截至2020年4月9日,5组家庭全员好转出院,1组3例重症患者仍在治疗,1组家庭内1例重症患者转院治疗,另有1组境外输入性病例已达出院标准,仍在隔离观察中。8组家庭最早及最晚发病(6.1±4.3)d,发病至就诊时间(4.3±3.9)d,核酸转阴时间(18.0±8.6)d,CT进展时间(9.6±3.3)d,CT病灶吸收时间(15.0±2.9)d,总病程(20.2±6.3)d。结论新型冠状病毒肺炎以同胞感染和父母-子女感染这两种聚集方式最为多见,家庭内部成员的CT表现的确具有一定相似性,但是因为部分家庭成员发病时间不同,故其胸部CT影像所处阶段如早期及进展期,亦有一定差异性,但总体上病情进展时病灶分布特点逐渐趋于一致。Objective To investigate the chest CT manifestations and outcomes of 25 cases of family clustering coronavirus disease 2019(COVID-19)in 8 families.Methods Retrospectively,clinical and CT imaging data of 8 groups of family clustering COVID-19 patients admitted to the Eighth People's Hospital of Guangzhou was collected.Results Seven patients(28.0%)had negative chest CT from onset,cured to discharged.Another 4 patients(16.0%)had a positive chest CT 6 days after admission.Two patients(8.0%)had scattered single lung lobe and 16 patients(64.0%)with a multiple lesion of both lungs,mainly manifested by ground glass shadow(16/25,64.0%);while a few fibrous cord shadow and ground glass shadow coexist(2/25,8.0%),and some are accompanied by bilateral pleural thickening(3/25,12.0%).On April 9,2020,all groups of 5 families were discharged from the hospital,1 group of 3 critically ill patients was still being treated,1 group of 1 severely ill patient was transferred to hospital for treatment,and another 1 group of imported cases has reached the discharge standard,but still under isolation observation.The earliest and latest onset of 8 groups of families was(6.1±4.3)d,time from onset to visit was(4.3±3.9)d,nucleic acid negative time was(18.0±8.6)d,CT progression time was(9.6±3.3)d,CT absorption time was(15.0±2.9)d,and the total course of disease was(20.2±6.3)d.Conclusion COVID-19 and HBV family clustering pattern infections are the same.The two aggregation methods of sibling infection and parent-child infection are the most common.The CT performance of family members does have certain similarities,but because some family members have different onset times,there are some differences in the stage of the chest CT image,the early stage and the advanced stage,but the overall distribution characteristics of the lesions gradually progress toward the same when the disease progresses.

关 键 词：家族聚集性 新型冠状病毒肺炎 体层摄影术 X线计算机 转归 

分 类 号：R563.1[医药卫生—呼吸系统] R816.4[医药卫生—内科学]