同型半胱氨酸与绝经后女性颈动脉粥样硬化的相关性研究  

Correlation between homocysteine and carotid atherosclerosis in postmenopausal women

作　　者：李婧[1] 林松柏[1] LI Jing;LIN Song-bai(Health Science Department,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]北京协和医院健康医学部,北京100730

出　　处：《实用预防医学》2020年第6期696-698,共3页Practical Preventive Medicine

摘　　要：目的研究同型半胱氨酸(homocysteine,Hcy)是否为绝经后女性颈动脉粥样硬化的独立风险因素。方法对2017年12月—2018年12月北京协和医院健康体检的1 204名55岁以上绝经后女性,进行Hcy检测和颈动脉超声检查。使用多变量logistic回归方法分析Hcy及其他传统风险因素对颈动脉粥样硬化的影响。结果 Hcy平均值(12.4±3.3)μmol/L,高Hcy血症176人(14.62%)。Hcy与年龄和BMI正相关(分别r=0.19,P<0.001;r=0.11,P<0.001)。颈动脉粥样硬化患者的Hcy显著升高(Z=-2.56,P=0.011)。logistic回归显示,对于颈动脉粥样硬化只有年龄(OR=1.11,95%CI:1.09~1.14)和收缩压(OR=1.02,95%CI:1.01~1.02)是独立风险因素;对颈动脉斑块形成年龄(OR=1.10,95%CI:1.08~1.12)、收缩压(OR=1.02,95%CI:1.01~1.03)、糖化血红蛋白(OR=1.27,95%CI:1.07~1.50)和高血压病史(OR=1.40,95%CI:1.06~1.87)是独立危险因素。结论在绝经后女性,Hcy不是动脉粥样硬化发生的独立风险因素,筛查高Hcy血症在预防该人群颈动脉粥样硬化的意义仍需进一步证明。Objective To determine if homocysteine(Hcy)is an independent risk factor for carotid atherosclerosis in postmenopausal women.Methods Determination of serum Hcy and carotid artery ultrasound examination were performed in 1,204 postmenopausal women aged above 55 years and undergoing physical examination in Peking Union Medical College Hospital from December 2017 to December 2018.Multivariate logistic regression was used to analyze the impact of Hcy and other traditional risk factors on carotid atherosclerosis.Results The mean level of Hcy was(12.4±3.3)μmol/L,and 176(14.62%)women had hyperhomocysteinemia.Hcy was positively correlated with age(r=0.19,P<0.001)and body mass index(r=0.11,P<0.001).Serum Hcy levels of patients with carotid atherosclerosis significantly increased(Z=-2.56,P=0.011).Logistic regression analysis revealed that only age(OR=1.11,95%CI:1.09-1.14)and systolic pressure(OR=1.02,95%CI:1.01-1.02)were independent risk factor for carotid atherosclerosis,while age(OR=1.10,95%CI:1.08-1.12),systolic pressure(OR=1.02,95%CI:1.01-1.02),glycated hemoglobin(OR=1.27,95%CI:1.07-1.50)and history of hypertension(OR=1.40,95%CI:1.06-1.87)were independent risk factors for carotid plaque.Conclusions Hcy is not an independent risk factor for carotid atherosclerosis in postmenopausal women;and hence,the significance of screening of hyperhomocysteinemia in carotid atherosclerosis prevention among this population remains to be further demonstrated.

关 键 词：绝经 同型半胱氨酸 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]