新疆汉、维、哈三民族人群酒精依赖者糖缺陷转铁蛋白含量的测定与差异分析  

Determination and difference analysis of carbohydrate deficient transferrin among Han,Uygur and Hazac three nationalities in Xinjiang

作　　者：黄培培 艾克拜尔·热合曼 米尔孜合买提·买买提明 阿尔孜古丽·木塔力甫[4] 谢辉[5] 

机构地区：[1]齐鲁医药学院机能学实验中心,山东淄博255000 [2]宁德师范学院化学与材料学院,福建宁德352100 [3]乌鲁木齐市第四人民医院戒酒科,新疆乌鲁木齐830000 [4]新疆维吾尔自治区人民医院临床检验中心,新疆乌鲁木齐830001 [5]新疆医科大学法医学教研室,新疆乌鲁木齐830011

出　　处：《科学技术创新》2020年第18期170-173,共4页Scientific and Technological Innovation

基　　金：国家自然科学基金(81360466)。

摘　　要：目的:探讨新疆汉、维、哈三民族人群之间酒精依赖者糖缺陷转铁蛋白(CDT)的含量差异。方法:选择新疆汉、维、哈三个民族作为研究对象,并将每个民族分为未饮酒者组、偶尔饮酒者组、酒精依赖者组。使用毛细管电泳仪Capillarys与Capillarys CDT试剂盒检测三个不同民族中三组人员的血清CDT含量。结果:与未饮酒健康者组和偶尔饮酒者组比较,酒精依赖者组的糖缺陷转铁蛋白含量明显升高,差异有统计学意义(P<0.001)。新疆酒精依赖者组三个不同民族的CDT含量间差异有统计学意义(P<0.05)。检测样本(n=368)CDT遗传变异的频率是4.07%。结论:CDT是一个灵敏度、特异性最佳的标记物,将作为司法鉴定酒精依赖的标记物。Objective:The different content of carbohydrate deficient Transferrin(CDT)has been detected among the nationalities of Han,Uygur and Hazac in Xinjiang.Methods:The nationalities of Han,Uygur and Hazac in Xinjiang were selected as the research groups,in which each of group was divided into three subgroups including the non-drinkers,occasional drinkers,and alcohol dependence.The CDT of three subgroups was detected by the capillary electrophoresis and Capillarys CDT kits.Results:The CDT level in the alcohol dependence was significantly increased than in the non-drinkers and the occasional drinkers,and the difference was statistically significant(P<0.001).The content of CDT in the alcohol-dependent group had significant differences among three different nationalities in Xinjiang(P<0.05).And the frequency of transferrin genet variation was 4.07%.Conclusion:The CDT is considered as a better detected indicator of sensitivity and specificity in forensic science.

关 键 词：糖缺陷转铁蛋白 酒精滥用与依赖 毛细管电泳 

分 类 号：R595.6[医药卫生—内科学]