高血压患者血清碱性磷酸酶与颈动脉硬化的相关性分析  

Analysis of correlation between serum alkaline phosphatase and carotid atherosclerosis in patients with hypertension

作　　者：沈群弟 周月琴[1] 凌迎春[1] SHEN Qundi;ZHOU Yueqin;LING Yingchun(Department of Laboratory Medicine,the Seventh People's Hospital of Shaoxing City in Zhejiang Province,Shaoxing 312000,China)

机构地区：[1]浙江省绍兴市第七人民医院检验科,浙江绍兴312000

出　　处：《中国现代医生》2020年第11期146-149,共4页China Modern Doctor

基　　金：国家自然科学基金(11574210)。

摘　　要：目的探讨高血压患者血清碱性磷酸酶(alkaline phosphatase,ALP)与颈动脉硬化的相关性。方法选取我院2016年6月~2018年12月住院或门诊的高血压患者100例,所有患者抽取空腹静脉血测定主要生化指标,并行颈动脉窦内膜-中层厚度(intima-media thickness,IMT)检查,使用颈动脉血管B超检查IMT,根据检测结果分为颈动脉IMT正常组、颈动脉IMT增厚组、颈动脉斑块形成组;依据所测的血清ALP水平四分位数分为四组:Q1组、Q2组、Q3组、Q4组。结果四组患者颈动脉IMT、劲动脉斑块形成比较,差异有统计学意义(P均<0.005)。各组两两比较,血清LDL-C水平,Q1组低于Q4组;颈动脉IMT,Q1组分别低于Q2组、Q3组和Q4组,Q2组低于Q4组;颈动脉斑块发生率,Q1组、Q2组低于Q4组,差异有统计学意义(P<0.05)。颈动脉IMT与年龄呈正相关(r=0.598,P=0.000),颈动脉IMT与LDL-C(low density lipoprotein cholesterol,LDL-C)呈正相关(r=0.468,P=0.007);血清ALP水平,颈动脉IMT增厚组高于颈动脉IMT正常组;颈动脉斑块形成组高于颈动脉IMT正常组和颈动脉IMT增厚组,差异有统计学意义(P<0.05),颈动脉IMT与血清ALP水平呈正相关(r=0.545,P=0.000);多元Logistic回归分析,影响颈动脉硬化的独立相关因素包括年龄、LDL-C及ALP。结论血清ALP水平是一个重要的影响高血压患者动脉粥样硬化的因素,可作为高血压患者动脉粥样硬化评估的标志物。Objective To investigate the correlation between serum alkaline phosphatase(ALP)and carotid atherosclerosis in patients with hypertension.Methods 100 patients with hypertension who were hospitalized or treated in the Outpatient Department of our hospital from June 2016 to December 2018 were selected.Fasting venous blood was extracted from all patients to determine the main biochemical indexes,the intima-media thickness(IMT)at carotid sinus was examined,and carotid artery B-mode ultrasound was used to examine IMT.According to the test results,the patients were divided into the normal carotid IMT group,the carotid IMT thickening group,and the carotid plaque formation group;according to the measured quartiles of serum ALP level,they were divided into four groups:group Q1,group Q2,group Q3,and group Q4.Results There were statistically significant differences in carotid IMT and carotid plaque formation among the four groups of patients(P<0.05).Comparing the two groups,the serum LDL-C level in the group Q1 was lower than that in the group Q4;Carotid IMT in the group Q1 was lower than that in the group Q2,group Q3 and group Q4,respectively,and that in the group Q2 was lower than that in the group Q4;The incidence of carotid plaque in the group Q1 and group Q2 was lower than that in the group Q4,The difference was statistically significant(P<0.05).Carotid IMT was positively correlated with age(r=0.598,P=0.000),and carotid IMT was positively correlated with low density lipoprotein cholesterol(LDL-C)(r=0.468,P=0.007);The serum ALP level in the carotid IMT thickening group was higher than that in the normal carotid IMT group and in the carotid IMT thickening group;That in the carotid plaque formation group was higher than that in the normal carotid IMT group,the difference was statistically significant(P<0.05)and there was a positive correlation between the carotid IMT and serum ALP level(r=0.545,P=0.000);Multivariate Logistic regression analysis showed that age,LDL-C and ALP were the independent correlated factors affectin

关 键 词：高血压 碱性磷酸酶 颈动脉硬化 内膜-中层厚度 

分 类 号：R544.11[医药卫生—心血管疾病]