支气管哮喘患儿25羟维生素D水平及其与总免疫球蛋白E的相关性研究  

Relationship between the serum levels of 25-hydroxyvitamin D and TIgE in children with asthma

作　　者：沈广娥 花梅娟 Shen Guangb;Hua Meijuan(Department of Paediatrics,the Fourth Peoples Hospital of Taizhou,Taizhou,Jiangsu 225300,China)

机构地区：[1]泰州市第四人民医院儿科,江苏省225300

出　　处：《中国基层医药》2020年第8期906-908,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：江苏省泰州市社会发展资助项目(TS201336)。

摘　　要：目的了解支气管哮喘患儿血清25羟维生素D水平,并分析其与总免疫球蛋白E(IgE)的关系。方法选取泰州第四人民医院儿科2013年10月至2014年9月门诊或住院治疗的支气管哮喘患儿48例为哮喘组,以同期在儿童保健门诊体检的健康儿童35例为对照组,比较两组血清25羟维生素D及总IgE水平,采用Pearson相关性分析分析25羟维生素D与总IgE的关系。结果哮喘组血清25羟维生素D为(35.86±14.31)nmol/L,明显低于对照组的(53.91±22.71)nmol/L,而IgE为(331.66±223.67)IU/mL,明显高于对照组的(99.33±86.50)IU/mL,差异均有统计学意义(t=4.32、2.36,均P<0.05);哮喘组患儿血清25羟维生素D与IgE呈负相关(r=-0.400,P<0.05)。结论支气管哮喘患儿25羟维生素D水平低于健康儿童,补充维生素D可能对预防和控制哮喘有一定的临床作用。Objective To measure the serum levels of 25-hydroxyvitamin D in children with asthma,and to investigate the relationship between the serum levels of 25-hydroxyvitamin D and total immunoglobulin E(TIgE).Methods From October 2013 to September 2014,48 children with bronchial asthma were selected as asthma group,and 35 healthy children were selected as control group.Double-antibody radioimmunoassay(RIA)was used to detect the levels of serum 25-hydroxyvitamin D and TIgE.Results The serum level of 25-hydroxyvitamin D in the asthma group was(35.86±14.31)nmol/L,which was significantly lower than that in the control group[(53.91±22.71)nmol/L],and IgE level in the asthma group was(331.66±223.67)IU/mL,which was significantly higher than that in the control group[(99.33±86.50)IU/mL],the differences were statistically significant(t=4.32,2.36,all P<0.05).There was a negative correlation between serum 25-hydroxyvitamin D and IgE in the asthma group(r=-0.400,P<0.05).Conclusion The serum levels of 25-hydroxyvitamin D may be associated with childhood asthma.The significant negative correlation between the levels of 25-hydroxyvitamin D and TIgE in children who had bronchial asthma indicates that asthma has a close relationship with allergy.Through increasing the concentration of 25-hydroxyvitamin D may prevent or treat child-hood asthma.

关 键 词：哮喘 羟基胆骨化醇类 24 25-二羟维生素D3 免疫球蛋白E 串联质谱法 酶联免疫吸附测定 儿童 

分 类 号：R72[医药卫生—儿科]