缺血性脑卒中后血管新生及针灸干预机制研究  

Study on Vascular Regeneration and Acupuncture Intervention Mechanism of Ischemic Stroke

作　　者：彭拥军[1] 徐疏影 李忠仁[2] 洪浩[2] 蔡云[2] 吴旭[1] 朱冰梅 PENG Yongjun;XU Shuying;LI Zhongren;HONG Hao;CAI Yun;WU Xu;ZHU Bingmei(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China;Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China;West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学,江苏南京210029 [3]四川大学华西医院,四川成都610041

出　　处：《辽宁中医药大学学报》2020年第4期8-12,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81973932,81574060,81001556);中国博士后科学基金(2015M571790);江苏省中医院院级课题省级康复中心建设专项项目(Y17kf02-5);第六批全国老中医药专家学术经验继承人项目。

摘　　要：缺血性脑卒中发生后的血管新生可改善缺血半暗带区域血流量,增加受损带的氧供应,减少梗死面积,并对神经功能的恢复有促进作用。而影响脑缺血后血管新生的机制十分复杂,是近年来研究脑缺血的热点问题。现下,脑缺血后血管新生不仅作为临床评判脑卒中预后的重要指标,同时也是治疗缺血性脑卒中的药物靶点。针灸作为中国传统医学,治疗缺血性脑卒中疗效显著,已受到国内外学者广泛认可。该文综述了脑缺血后血管新生的调控机制及其为针灸治疗脑卒中所提供理论依据。After the occurrence of ischemic stroke,angiogenesis can improve the blood flow in isch emic penumbra,increase the oxygen supply in the damaged area,reduce the infarct area,and promote the recovery of nerve function. However,the mechanism of angiogenesis after cerebral ischemia is very complex,which has been a hot topic in recent studies on cerebral ischemia. Currently,angiogenesis after cerebral ischemia is not only an important indicator for clinical evaluation of stroke prognosis,but also a drug target for the treatment of ischemic stroke. As a traditional Chinese medicine,acupuncture and moxibustion has a significant effect on the treatment of ischemic stroke,and has been widely recognized by scholars at home and abroad. This article reviews the regulatory mechanism of cerebral ischemia and the theoretical basis for acupuncture and moxibustion in the treatment of cerebral apoplexy.

关 键 词：缺血性脑卒中 血管新生 针灸 综述 

分 类 号：R255.2[医药卫生—中医内科学] R743.3[医药卫生—中医学]