基于Wnt/β-catenin通路中医药疗法治疗骨相关疾病研究进展  

Research Progress of Chinese Medicine Therapy Based on Wnt/β-catenin Pathway in the Treatment of Bone-related Diseases

作　　者：李涛[1] 吴山[2] 范志勇[2] 田强[2] 郭汝松[2] LI Tao;WU Shan;FAN Zhiyong;TIAN Qiang;GUO Rusong(Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China;Guangdong Hospital of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510006 [2]广东省中医院,广东广州510405

出　　处：《辽宁中医药大学学报》2020年第4期117-121,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81874511)。

摘　　要：中医药疗法治疗骨相关疾病疗效显著,近年,Wnt/β-catenin信号通路受到越来越多的关注,基于该通路研究中医药疗法干预骨相关疾病的工作取得不少进展,中医药治疗骨相关疾病得到分子生物学层面的证据。进一步深化中医药疗法治疗骨相关疾病的研究,可以为骨相关疾病的临床治疗开辟出新思路。因此,对基于经典Wnt/β-catein信号通路的中医药治疗骨相关疾病的研究进展进行综述。Traditional Chinese medicine is efficient to bone-related diseases. The Wnt/β-catenin signaling pathway is receiving increasing attention. Based on this pathway,the researches on TCM therapies treating bone-related diseases have made great progress. The mechanism of TCM on bone-related diseases has obtained molecular-biological evidence. If we further study the traditional Chinese medical therapies on bone-related diseases,we might develop new clinical treatments on bone-related diseases. Therefore,we reviewed the research progress of traditional Chinese medicine based on Wnt/β-catenin signaling pathway in the treatment of bone-related diseases.

关 键 词：WNT/Β-CATENIN信号通路 中医药 疗法 骨相关疾病 研究进展 骨质疏松 股骨头坏死 强直性脊柱炎 骨性关节炎 类风湿关节炎 椎间盘退变 

分 类 号：R714.257[医药卫生—妇产科学]