曼月乐联合GnRH-α对子宫腺肌症患者子宫血流动力学及炎症因子水平的影响  

Effects of Manyule Combined with GnRH-αon Uterine Hemodynamics and Inflammatory Factors in Patients with Adenomyosis

作　　者：李文超[1] LI Wen-chao(Department of Obstetrics and Gynecology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯市中心医院妇产科,黑龙江佳木斯154002

出　　处：《医学信息》2020年第11期147-148,共2页Journal of Medical Information

摘　　要：目的探讨曼月乐联合促性腺激素释放激素激动剂类药物(GnRH-α)对子宫腺肌症患者血流动力学及炎症因子水平的影响。方法选择2018年4月~2019年5月佳木斯市中心医院妇产科收治的子宫腺肌症患者94例,按随机数表法分为对照组和观察组,各47例。对照组采用曼月乐联合屈螺酮炔雌醇治疗,观察组采用曼月乐联合GnRH-α治疗,比较两组治疗3个月后血流动力学[子宫动脉的最大血流速度(Vmax)、最小血流速度(Vmin)和阻力指数(RI)]、炎症因子水平[血清基质金属蛋白酶2(MMP-2)以及基质金属蛋白酶9(MMP-9)]。结果治疗后,观察组子宫动脉Vmax[(20.73±1.98)cm/s]、Vmin[(9.21±0.84)cm/s]均低于对照组的(25.67±2.11)cm/s、(12.54±1.13)cm/s,RI为(0.81±0.13),高于对照组的(0.81±0.13)(P<0.05);治疗后观察组MMP-2为(59.64±4.32)ng/ml,MMP-9为(67.22±2.65)ng/ml,低于对照组的(66.35±6.28)ng/ml、(73.68±3.47)ng/ml(P<0.05)。结论子宫腺肌症患者采用曼月乐联合GnRH-α治疗有助于减小子宫体积及子宫内膜厚度,改善血流状况,降低炎症因子水平。Objective To investigate the effect of Manyule combined with gonadotropin-releasing hormone agonist(GnRH-α)on hemodynamics and inflammatory factors in patients with adenomyosis.Methods From April 2018 to May 2019,94 patients with adenomyosis were treated in the Obstetrics and Gynecology Department of Jiamusi Central Hospital,and they were divided into a control group and an observation group according to the random number table method,each with 47 cases.The control group was treated with Manyule and drospirenone ethinylestradiol,and the observation group was treated with Manyule and GnRH-α,comparing the hemodynamics of the two groups after 3 months of treatment[Maximum blood flow velocity of uterine artery(Vmax),minimum blood flow velocity(Vmin)and resistance index(RI)]and inflammatory factor levels[serum matrix metalloproteinase 2(MMP-2)and matrix metalloproteinase 9(MMP-9)].Results After treatment,the uterine artery Vmax[(20.73±1.98)cm/s]and Vmin[(9.21±0.84)cm/s]of the observation group were lower than those of the control group(25.67±2.11)cm/s and(12.54±1.13)cm/s s,RI was(0.81±0.13),higher than the control group(0.81±0.13)(P<0.05);MMP-2 in the observation group after treatment was(59.64±4.32)ng/ml,MMP-9 is(67.22±2.65)ng/ml,which is lower than that of the control group(66.35±6.28)ng/ml and(73.68±3.47)ng/ml(P<0.05).Conclusion The treatment of adenomyosis patients with Manyule combined with GnRH-αis helpful to reduce the uterine volume and endometrial thickness,improve blood flow status,and reduce the level of inflammatory factors.

关 键 词：子宫腺肌症 曼月乐 GNRH-Α 基质金属蛋白酶9 

分 类 号：R711.71[医药卫生—妇产科学]