肾衰宁联合贝前列素钠治疗老年慢性肾衰的疗效及对肾功能、氧化应激指标的影响  

Effects of Shenshuaining capsule combined with beraprost sodium on renal function and oxidative stress of elder⁃ly patients with chronic renal failure

作　　者：陈丽萍[1] 叶玉燕[1] 朱志伟[1] CHEN Liping;YE Yuyan;ZHU Zhiwei(Department of Nephrology,Jinhua People’s Hospital,Jinhua 321000,China)

机构地区：[1]金华市人民医院肾内科,浙江金华321000

出　　处：《全科医学临床与教育》2020年第5期435-437,共3页Clinical Education of General Practice

摘　　要：目的 探讨肾衰宁联合贝前列素钠治疗老年慢性肾衰的疗效及对肾功能和氧化应激的影响.方法 选择慢性肾衰老年患者100例,随机分为实验组和对照组,两组各50例.对照组采用贝前列素钠治疗,实验组采用肾衰宁胶囊联合贝前列素钠治疗,评估临床疗效,并检测肾功能、炎性因子和氧化应激相关指标.结果 实验组总有效率为82.00%,高于对照组64.00%,差异有统计学意义(χ2=4.11,P<0.05),实验组治疗后血尿素氮(BUN)、血肌酐(SCr)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和丙二醛(MDA)均低于对照组治疗后,差异均有统计学意义(t分别=16.44、6.24、10.13、3.73、19.46,P均<0.05);实验组治疗后肌酸酐清除率(Ccr)、肾小球过滤率(e-GFR)和超氧化物岐化酶(SOD)均高于对照组治疗后,差异均有统计学意义(t分别=24.51、12.06、8.46,P均<0.05).结论 肾衰宁联合贝前列素钠治疗老年慢性肾衰患者,临床疗效显著,能明显改善患者肾功能和氧化应激状况.Objective To explore the clinical efficacy of Shenshuaining capsule combined with beraprost sodium in the treatment of elderly patients with chronic renal failure.Methods Totally 100 elderly patients with chronic renal failure were selected and randomly divided into experimental group and control group according to the random number table,50 patients in each group.The control group were treated with beraprost sodium,experimental group was received Shenshuaining capsule combined with beraprost sodium.The clinical efficacy,renal function,inflammatory factors levels and oxidative stress related indicators were observed and compared.Results The total effective rate of the experimental group was 82.00%,which is higher than that of the control group(64.00%),the difference was statistically significant(χ2=4.11,P<0.05).After treatment,the levels of blood urea nitrogen(BUN),serum creatinine(SCr),hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and malondialdehyde(MDA)in experimental group were significantly lower than those in the control group(t=16.44,6.24,10.13,3.73,19.49,P<0.05),while the creatinine clearance,glomerular filtration rate and superoxide dismutase were higher than those in the control group(t=24.51,12.06,8.46,P<0.05).Conclusion Shenshuaining capsule combined with beraprost sodium in the treatment of elderly patients with chronic renal failure has the significant clinical effect and improve renal function and oxidative stress obviously.

关 键 词：肾衰宁胶囊 贝前列素钠片 慢性肾衰 临床疗效 肾功能 氧化应激 

分 类 号：R692.5[医药卫生—泌尿科学]