大环多胺型荧光探针的研究进展  

Progress of Fluorescent Probes Based on Macrocyclic Polyamine

作　　者：王小波 熊惠娟 吴莎莎 耿志荣 王志林 WANG Xiao-Bo;XIONG Hui-Juan;WU Sha-Sha;GENG Zhi-Rong;WANG Zhi-Lin(School of Pharmacy,Hubei University of Science and Technology,Xianning,Hubei 437100,China;School of Chemistry and Chemical Engineering,State Key Laboratory of Coordination Chemistry,Nanjing University,Nanjing 210023,China)

机构地区：[1]湖北科技学院药学院,咸宁437100 [2]南京大学化学化工学院,配位化学国家重点实验室,南京210023

出　　处：《无机化学学报》2020年第6期1035-1048,共14页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.21976080,21775069);湖北省自然科学基金(No.2018CFB323)资助。

摘　　要：大环多胺作为含有多个氮原子和闭合环状结构的一类电子供体,在构筑荧光探针方面具有独特的优势。代表性的大环多胺如四氮环(cyclen、cyclam和pyclen)和三氮环(tacn)等,它们被广泛用于金属离子、阴离子、生物活性小分子和生物大分子探针的识别基团或功能基团。本文依据检测对象的不同,综述近年来大环多胺在荧光探针的设计、制备及应用方面的优秀成果,并对未来其在荧光检测分析领域的进一步发展进行了展望。Macrocyclic polyamines are intriguing electron donors for constructing fluorescent probes due to their characteristics of ring configuration and a few nitrogen atoms.For example,typical tetraazamacrocycle such as cyclen(1,4,7,10-tetraazacyclododecane),cyclam(1,4,8,11-tetraazacyclotetradecane)and pyclen(1,4,7,10-tetraaza-2,6-pyridinophane),and triazamacrocycle tacn(1,4,7-triazacyclononane)which are widely employed as receptors or functional groups in fluorescent probes for recognition of metal ions,onions,small molecules and biomacromolecules.In this review,we highlight the many different detection targets and summarize the latest prominent research achievements in the design,preparation and application of fluorescent probes based on macrocyclic polyamines.Additionally,the future research interests and perspectives in the field of fluorescence analysis are also addressed.

关 键 词：大环多胺 荧光探针 1 4 7 10-四氮杂环十二烷 1 4 8 11-四氮杂环十四烷 细胞成像 

分 类 号：O641.4[理学—物理化学]