中年男性冠心病的发生和冠状动脉病变程度与H型高血压的关系  

Relationship of incidence of coronary heart disease and severity of coronary artery disease with H-type hypertension in middle-aged males

作　　者：周春光 冯霞 罗勇[3] ZHOU Chun-guang;FENG Xia;LUO Yong(Department of Cardiology,the First People′s Hospital of Guangyuan,Guangyuan 628000,China;Hemodialysis Room,the Third People′s Hospital of Guangyuan,Guangyuan 628000,China;Department of Cardiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]四川省广元市第一人民医院心内科,广元市628000 [2]四川省广元市第三人民医院血透室,广元市628000 [3]川北医学院附属医院心内科,四川省南充市637000

出　　处：《广西医学》2020年第10期1248-1251,1284,共5页Guangxi Medical Journal

摘　　要：目的探讨中年男性冠心病的发病和冠状动脉病变程度与H型高血压的相关性。方法选取231例疑诊为冠心病的中年男性为研究对象。根据冠状动脉造影结果分为冠心病组150例及非冠心病组81例,分析影响冠心病发病的因素。根据血同型半胱氨酸(Hcy)水平及是否合并高血压,将冠心病组进一步分为单纯高Hcy亚组46例、普通高血压亚组11例、H型高血压亚组83例和单纯冠心病亚组10例,比较各亚组间冠状动脉Gensini积分的差异。结果冠心病组患者的Hcy水平、合并H型高血压患者比例均高于非冠心病组,多因素Logistic回归分析结果显示,高Hcy水平、H型高血压均为中年男性冠心病发病的独立危险因素(均P<0.05)。H型高血压亚组的Gensini积分高于其他亚组(均P<0.05),而其他亚组间差异均无统计学意义(P>0.05)。结论H型高血压中年男性发生冠心病的风险增加,而在中年男性冠心病患者中,合并H型高血压者冠状动脉病变更重。Objective To explore the correlation of the incidence of coronary heart disease(CHD)and the severity of coronary artery disease with H-type hypertension in middle-aged males.Methods A total of 231 middle-aged males with suspected CHD were selected as research subjects.And they were divided into CHD group(n=150)and non-CHD group(n=81)according to the findings of coronary angiography,the factors influencing the incidence of CHD were analyzed.According to serum homocysteine(Hcy)level and the presence of complication of hypertension,the CHD group was further subdivided into simple high Hcy subgroup(n=46),common hypertension subgroup(n=11)and H-type hypertension subgroup(n=83)and simple CHD subgroup(n=10),coronary Gensini scores were compared among all subgroups.Results The CHD group experienced elevated Hcy level and higher proportion of cases complicated with H-type hypertension as compared with the non-CHD group,multivariate Logistic regression analysis results showed that high Hcy level and H-type hypertension were the independent risk factors for developing CHD in middle-aged males(all P<0.05).The H-type hypertension subgroup had higher Gensini scores than other subgroups(all P<0.05),and no statistically significant difference was found among other subgroups(P>0.05).Conclusion Middle-aged males with H-type hypertension have increased risk of developing CHD,and among middle-aged male patients with CHD,those complicated with H-type hypertension suffer from more severer coronary artery disease.

关 键 词：冠心病 H型高血压 同型半胱氨酸 冠状动脉病变 中年男性 

分 类 号：R541.4[医药卫生—心血管疾病]