我院碳青霉烯耐药的鲍曼不动杆菌分子流行病学研究  

The Insights into the Molecular Epidemiology of Carbapenem Resistant Clones of Acinetobacter Baumannii

作　　者：滑明溪 李敏[1] 王慧珠[1] 刘鑫喆 李国力[1] 杜娟[1] 刘景院[1] 王雅杰 李昂[1] HUA Mingxi;LI Min;WANG Huizhu;LIU Xinzhe;LI Guoli;DU Juan;LIU Jingyuan;WANG Yajie;LI Ang(Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China)

机构地区：[1]首都医科大学附属北京地坛医院,北京100015

出　　处：《标记免疫分析与临床》2020年第5期729-733,共5页Labeled Immunoassays and Clinical Medicine

基　　金：国家自然科学基金(编号:81902025);北京市医院管理局扬帆计划重点医学专业(编号:ZYLX2018-02-感染性疾病重症医学);北京市博士后科研活动经费(编号:ZZ 2019-019);北京市自然科学基金(编号:7184218)。

摘　　要：目的研究我院碳青霉烯耐药鲍曼不动杆菌(carbapenem-resistant Acinetobacter baumannii,CRAB)的流行病学特征。方法分析了我院2019年1月至7月,33株非重复CRAB的分子型别。结果多位点序列分型(multilocus sequence typing,MLST)结果显示,33株CRAB共有6种ST类型,其中四种属于CC92克隆群(ST195、ST208、ST369及ST540),另一个ST型别为ST229与另一株未归类的新ST型别(与ST540相差一个GDH位点)。对33株CRAB进行单核苷酸多态性(single-nucleotide polymorphisms,SNPs)分析结果,显示CC92克隆群中基因组相似性与ST型别差异并不一致。结论由于SNP方法在分析基因组相似度方面更加精确,SNP可能能够成为预防和监测院内感染暴发的新标准。Objective To study the epidemiological characteristics of Acinetobacter baumannii(CRAB)in our hospital.Methods we analyzed the multilocus sequence Typing(MLST)of results of 33 CRAB obtained from January to July of 2019 in our hospital.Results There were 6 ST types in 33 CRABs,most of which belong to CC92 clonal group(ST195,ST208,ST369 and ST540),and other ST types were ST229 and a new ST type(a GDH site difference with ST540).The single nucleotide polymorphism(SNPs)analysis showed that the genomic similarity was not consistent with the MLST.Conclusion Due to the more accurate feature in analyzing genomic similarity,SNP may become a new standard for preventing and monitoring outbreaks of CRAB nosocomial infections.

关 键 词：鲍曼不动杆菌 多位点序列分型 单核苷酸多态性分析 院内暴发 

分 类 号：R392[医药卫生—免疫学]