绝经后外阴阴道萎缩治疗的研究进展  

Research Progress on the Treatment of Vulvar and Vaginal Atrophy in Post-Menopausal Women

作　　者：陈雅雪 刘新莲[1] 丁岩(审校)[1] CHEN Ya-xue;LIU Xin-lian;DING Yan(Department of Obstetrics and Gynecology,First Affiliated to Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院妇产科,乌鲁木齐830054

出　　处：《国际妇产科学杂志》2020年第3期301-305,共5页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81660249)。

摘　　要：外阴阴道萎缩为常见的绝经后症状,主要表现为阴道干涩、性交困难、灼烧痛等,可影响患者生活和工作。越来越多的绝经后妇女有治疗外阴阴道萎缩的需求,以期获得更高的生活质量。根据2007年北美绝经协会立场声明,目前外阴阴道萎缩最常用的治疗方式为局部雌激素治疗,该方法为一线治疗方式,但部分患者对激素治疗难以接受或有使用激素治疗的禁忌证,故衍生出了阴道保湿剂、选择性雌激素受体调节剂、普拉睾酮、激光、中医药等治疗方式。现就外阴阴道萎缩不同的治疗方式及其作用机制、适用患者等进行综述,以期为临床用药提供参考。Vulvar and vaginal atrophy is a common symptom in postmenopausal women,the most prevalent symptoms are vaginal dryness,dyspareunia,vaginal irritation or itching,can disturb patients′life and work.More and more patients need therapy in order to obtain a higher quality of life.According to the NAMS′s guidelines,the most common treatment of vulvar and vaginal atrophyis local hormone therapy in recent years.This method is first-line treatment.But some patients have difficulty to accept hormone therapy,or have contraindication of hormone treatment.Therefore,vaginal moisturizer,selective estrogen receptor modulator,prasterone,laser,traditional Chinese medicine and other treatment methods are derived.This paper will review the different treatment methods and mechanism and its application in patients,in order to provide reference for the treatment of vulvovaginal atrophy.

关 键 词：绝经后期 外阴 阴道 萎缩 治疗 生活质量 

分 类 号：R711.72[医药卫生—妇产科学]