小剂量肝素钠联合红花黄色素治疗老年慢性阻塞性肺疾病急性加重期的临床疗效  

Clinical effect of low dose heparin sodium combined with safflower yellow pigment for acute exacerbation of chronic obstructive pulmonary disease in the elderly

作　　者：高峰 韦彬祥 卢肖芳 GAO Feng;WEI Bin-xiang;LU Xiao-fang(Gaozhou Chronic Disease Prevention and Control Station,Gaozhou 525200,China)

机构地区：[1]广东省高州市慢性病防治站,525200 [2]广东省高州市第二人民医院,525200

出　　处：《临床合理用药杂志》2020年第12期1-2,5,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨小剂量肝素钠联合红花黄色素治疗老年慢性阻塞性肺疾病(COPD)急性加重期的临床疗效。方法选取高州市第二人民医院2017年8月—2018年12月收治的COPD急性加重期患者88例,随机分为对照组和观察组,各44例。对照组给予小剂量肝素钠治疗,观察组在对照组基础上给予红花黄色素治疗。两组均连续治疗2周。比较两组临床疗效,治疗前后症状和体征评分、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、血氧饱和度(SpO2)、第一秒用力呼气末容积占预计值百分比(FEV1%)、FEV1/用力肺活量(FVC)比值。结果观察组总有效率高于对照组(P<0.05)。治疗前两组症状和体征评分、PaO2、PaCO2、SpO2比较,差异无统计学意义(P>0.05);治疗后观察组症状和体征评分、PaCO2低于对照组,PaO2、SpO2高于对照组(P<0.05)。治疗前两组FEV1%、FEV1/FVC比较,差异无统计学意义(P>0.05);治疗后观察组FEV1%、FEV1/FVC高于对照组(P<0.05)。结论小剂量肝素钠联合红花黄色素治疗COPD急性加重期的临床疗效确切,可有效改善临床症状和体征、动脉血气分析指标和肺功能指标。Objective To investigate the clinical effect of low dose heparin sodium combined with safflower yellow pigment for acute exacerbation of chronic obstructive pulmonary disease(COPD)in the elderly.Methods A total of 88 cases of patients with acute exacerbation of COPD were selected from August 2017 to December 2018 in the Second People’s Hospital of Gaozhou,which were randomly divided into control group and observation group,44 cases each of group.The control group was treated with low dose heparin sodium,and the observation group was treated with safflower yellow pigment based on the control group.Both groups were treated for 2 weeks.The clinical effects of the two groups were compared,symptoms and signs scores,PaO2,PaCO2,SpO2,FEV1%,FEV1/FVC ratio were compared between the two groups before and after treatment.Results The total effective rate of the observation group was higher than the control group(P<0.05).There was no significant difference in the scores of symptoms and signs,PaO2,PaCO2 and SpO2 between the two groups before treatment(P>0.05);after treatment,the scores of symptoms and signs,PaCO2 in the observation group was lower than the control group,and PaO2 and SpO2 were higher than the control group(P<0.05).There was no significant difference in FEV1%and FEV1/FVC between the two groups before and after treatment(P>0.05);after treatment,FEV1%and FEV1/FVC in the observation group were higher than the control group(P<0.05).Conclusion Low dose heparin sodium combined with safflower yellow pigment is effective for acute exacerbation of COPD,which can effectively improve the clinical symptoms and signs,arterial blood gas index and pulmonary function index.

关 键 词：肺疾病 慢性阻塞性 急性加重期 小剂量肝素钠 红花黄色素 治疗结果 

分 类 号：R563.9[医药卫生—呼吸系统]